Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Relationship between immune response of elderly subjects and number of annual seasonal immunizations with live and inactivated influenza vaccines. / Naikhin, AN; Rudenko, LG; Arden, N; Katz, J; Grigoryeva, YP; Donina, SA; Desheva, YA; Rextin, AR; Cox, N.
в: Voprosy Virusologii, Том 43, № 3, 1998, стр. 130-134.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Relationship between immune response of elderly subjects and number of annual seasonal immunizations with live and inactivated influenza vaccines
AU - Naikhin, AN
AU - Rudenko, LG
AU - Arden, N
AU - Katz, J
AU - Grigoryeva, YP
AU - Donina, SA
AU - Desheva, YA
AU - Rextin, AR
AU - Cox, N
PY - 1998
Y1 - 1998
N2 - A total of 159 subjects aged 65-87 years were immunized with live cold-adapted reassortant influenza vaccine (CRIV), inactivated influenza vaccine (IIV), and with both vaccines (CRIV+IIV) one year, two and three years running. The frequency and intensity of accumulation of postvaccinal secretory and humoral antibodies in elderly subjects depend on the scheme of immunization and history of vaccinations. Combination of the two vaccines effectively stimulated both components of immunity and ensured a longer persistence of postvaccinal antibodies in high concentrations. Immunization with CRIV+IIV for three years resulted in a gradual increase of the intensity of prevaccination secretory and humoral immunity. Before the third seasonal immunization the majority (63-75%) of vaccinees had antibodies in protective titers.
AB - A total of 159 subjects aged 65-87 years were immunized with live cold-adapted reassortant influenza vaccine (CRIV), inactivated influenza vaccine (IIV), and with both vaccines (CRIV+IIV) one year, two and three years running. The frequency and intensity of accumulation of postvaccinal secretory and humoral antibodies in elderly subjects depend on the scheme of immunization and history of vaccinations. Combination of the two vaccines effectively stimulated both components of immunity and ensured a longer persistence of postvaccinal antibodies in high concentrations. Immunization with CRIV+IIV for three years resulted in a gradual increase of the intensity of prevaccination secretory and humoral immunity. Before the third seasonal immunization the majority (63-75%) of vaccinees had antibodies in protective titers.
KW - influenza vaccines
KW - elderly subjects
KW - immunization schemes
KW - immune response
KW - COLD-ADAPTED INFLUENZA
KW - A VIRUS-VACCINES
KW - VACCINATION
KW - ANTIBODIES
KW - EFFICACY
M3 - статья
VL - 43
SP - 130
EP - 134
JO - Вопросы вирусологии
JF - Вопросы вирусологии
SN - 0507-4088
IS - 3
ER -
ID: 61121365