Regulatory mechanisms for apoptosis in placental tissue during normal pregnancy and gestosis-complicated pregnancy

D. I. Sokolov, A. V. Kolobov, M. V. Lesnichija, I. N. Kostiouchek, O. I. Stepanova, I. M. Kvetnoy, S. A. Selkov

Результат исследований: Научные публикации в периодических изданияхстатья

10 Цитирования (Scopus)

Аннотация

The localization of apoptosis and expression of proapoptotic and antiapoptotic factors by the placental tissue were compared during normal pregnancy and gestosis-complicated pregnancy. The degree of apoptosis did not differ in the third trimester of normal pregnancy and gestosis-complicated pregnancy. Increased expression of Fas, caspase-8, and caspase-3 in placental tissue during normal pregnancy was shown to contribute to the suppression of angiogenesis and growth of placental tissue. No differences were found in the expression of FasL (CD95L), caspase-2, caspase-9, and Mcl-1 by placental cells during normal pregnancy and gestosis-complicated pregnancy. Increased expression of TRAIL by trophoblast cells is a protective mechanism from apoptotic signals of maternal cytotoxic lymphocytes and NK cells during gestosis.

Язык оригиналаанглийский
Страницы (с-по)766-770
Число страниц5
ЖурналBulletin of Experimental Biology and Medicine
Том148
Номер выпуска5
DOI
СостояниеОпубликовано - 1 ноя 2009

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Предметные области Scopus

  • Биохимия, генетика и молекулярная биология (все)

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