Despite impressive progress in molecular biology and genetics over the last decades, the key question is still unanswered—why the genetic code is triplet and what information it keeps and transfers over translation. Unexpectedly, the answer comes not from biology but from spin physics and computational quantum chemistry. The study aims to shed light on howmRNAsees the right tRNA and what sort of communication ensures the codon–anticodon recognition. The data rests on the quantum mechanical/molecular mechanical quantum chemistry computations of the mRNA-tRNA fragments differing in 61 codon–anticodon nucleotide triplets coding 20 canonical amino acids.
Предметные области Scopus
- Биохимия, генетика и молекулярная биология (все)
- magnesium cofactor, translation, mRNA-tRNA interaction, codon–anticodon communication, spin physics, QM/MM computations