Predator Odor Destabilizes the Cell Genome of the Mouse Bone Marrow

T. S. Glinin, Polina Starshova, V. A. Shubina, M. V. Anisimova, A. A. Bondarenko, M. P. Moshkin, E. V. Daev

Результат исследований: Научные публикации в периодических изданияхстатья

Выдержка

The effect of urine chemosignals of domestic male cats (Felis catus L.) on the stability of the bone marrow cell genome and corticosterone level in blood plasma of recipient mice (Mus musculus L.) is studied. It is demonstrated that a two-hour sniffing of volatile chemosignals leads to an increase in the frequency of bone marrow cells with damaged DNA, while 24 h exposure to chemosignals leads to an increase of chromosomal aberrations frequency in these cells. Thus, the effect of genomic instability induction in bone marrow cells of house mice by predator’s chemosignals is for the first time demonstrated in the work. At the same time, no increase in the corticosterone level is detected in the blood plasma either 30 or 60 min after the beginning of the exposure to the chemosignals of cat urine (CU). The physiological factors contributing to DNA damages accumulation in bone marrow cells, as well as the long-term consequences of the effect of these chemosignals on the genome stability, are discussed.

Язык оригиналаанглийский
Страницы (с-по)101-107
Число страниц7
ЖурналRussian Journal of Genetics: Applied Research
Том8
Номер выпуска2
DOI
СостояниеОпубликовано - 1 июл 2018

Отпечаток

bone marrow cells
Bone Marrow Cells
bone marrow
Bone Marrow
odors
Genome
predators
genome
Genomic Instability
mice
Mus musculus
corticosterone
Corticosterone
blood plasma
Cats
urine
Urine
cells
cats
chromosome aberrations

Предметные области Scopus

  • Зоология и животноводство
  • Генетика
  • Агрономия и растениеводство

Цитировать

Glinin, T. S. ; Starshova, Polina ; Shubina, V. A. ; Anisimova, M. V. ; Bondarenko, A. A. ; Moshkin, M. P. ; Daev, E. V. / Predator Odor Destabilizes the Cell Genome of the Mouse Bone Marrow. В: Russian Journal of Genetics: Applied Research. 2018 ; Том 8, № 2. стр. 101-107.
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abstract = "The effect of urine chemosignals of domestic male cats (Felis catus L.) on the stability of the bone marrow cell genome and corticosterone level in blood plasma of recipient mice (Mus musculus L.) is studied. It is demonstrated that a two-hour sniffing of volatile chemosignals leads to an increase in the frequency of bone marrow cells with damaged DNA, while 24 h exposure to chemosignals leads to an increase of chromosomal aberrations frequency in these cells. Thus, the effect of genomic instability induction in bone marrow cells of house mice by predator’s chemosignals is for the first time demonstrated in the work. At the same time, no increase in the corticosterone level is detected in the blood plasma either 30 or 60 min after the beginning of the exposure to the chemosignals of cat urine (CU). The physiological factors contributing to DNA damages accumulation in bone marrow cells, as well as the long-term consequences of the effect of these chemosignals on the genome stability, are discussed.",
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Glinin, TS, Starshova, P, Shubina, VA, Anisimova, MV, Bondarenko, AA, Moshkin, MP & Daev, EV 2018, 'Predator Odor Destabilizes the Cell Genome of the Mouse Bone Marrow', Russian Journal of Genetics: Applied Research, том. 8, № 2, стр. 101-107. https://doi.org/10.1134/S2079059718020041

Predator Odor Destabilizes the Cell Genome of the Mouse Bone Marrow. / Glinin, T. S.; Starshova, Polina; Shubina, V. A.; Anisimova, M. V.; Bondarenko, A. A.; Moshkin, M. P.; Daev, E. V.

В: Russian Journal of Genetics: Applied Research, Том 8, № 2, 01.07.2018, стр. 101-107.

Результат исследований: Научные публикации в периодических изданияхстатья

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AU - Shubina, V. A.

AU - Anisimova, M. V.

AU - Bondarenko, A. A.

AU - Moshkin, M. P.

AU - Daev, E. V.

PY - 2018/7/1

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N2 - The effect of urine chemosignals of domestic male cats (Felis catus L.) on the stability of the bone marrow cell genome and corticosterone level in blood plasma of recipient mice (Mus musculus L.) is studied. It is demonstrated that a two-hour sniffing of volatile chemosignals leads to an increase in the frequency of bone marrow cells with damaged DNA, while 24 h exposure to chemosignals leads to an increase of chromosomal aberrations frequency in these cells. Thus, the effect of genomic instability induction in bone marrow cells of house mice by predator’s chemosignals is for the first time demonstrated in the work. At the same time, no increase in the corticosterone level is detected in the blood plasma either 30 or 60 min after the beginning of the exposure to the chemosignals of cat urine (CU). The physiological factors contributing to DNA damages accumulation in bone marrow cells, as well as the long-term consequences of the effect of these chemosignals on the genome stability, are discussed.

AB - The effect of urine chemosignals of domestic male cats (Felis catus L.) on the stability of the bone marrow cell genome and corticosterone level in blood plasma of recipient mice (Mus musculus L.) is studied. It is demonstrated that a two-hour sniffing of volatile chemosignals leads to an increase in the frequency of bone marrow cells with damaged DNA, while 24 h exposure to chemosignals leads to an increase of chromosomal aberrations frequency in these cells. Thus, the effect of genomic instability induction in bone marrow cells of house mice by predator’s chemosignals is for the first time demonstrated in the work. At the same time, no increase in the corticosterone level is detected in the blood plasma either 30 or 60 min after the beginning of the exposure to the chemosignals of cat urine (CU). The physiological factors contributing to DNA damages accumulation in bone marrow cells, as well as the long-term consequences of the effect of these chemosignals on the genome stability, are discussed.

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Glinin TS, Starshova P, Shubina VA, Anisimova MV, Bondarenko AA, Moshkin MP и соавт. Predator Odor Destabilizes the Cell Genome of the Mouse Bone Marrow. Russian Journal of Genetics: Applied Research. 2018 Июль 1;8(2):101-107. https://doi.org/10.1134/S2079059718020041