TY - JOUR

T1 - Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies

AU - Kashatnikova, Darya A.

AU - Khadzhieva, Maryam B.

AU - Kolobkov, Dmitry S.

AU - Belopolskaya, Olesya B.

AU - Smelaya, Tamara V.

AU - Gracheva, Alesya S.

AU - Kalinina, Ekaterina V.

AU - Larin, Sergey S.

AU - Kuzovlev, Artem N.

AU - Salnikova, Lyubov E.

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022/8/31

Y1 - 2022/8/31

N2 - Pneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbidities as well as to assess the host immune response measured by TREC/KREC levels in patients with pneumonia. The theoretical study was carried out using the Columbia Open Health Data (COHD) resource, which provides access to clinical concept prevalence and co-occurrence from electronic health records. The experimental study included TREC/KREC assays in young adults (18–40 years) with community-acquired (CAP) (n = 164) or nosocomial (NP) (n = 99) pneumonia and healthy controls (n = 170). Co-occurring rates between pneumonia, sepsis, acute respiratory distress syndrome (ARDS) and some other related conditions common in intensive care units were the top among 4170, 3382 and 963 comorbidities in pneumonia, sepsis and ARDS, respectively. CAP patients had higher TREC levels, while NP patients had lower TREC/KREC levels compared to controls. Low TREC and KREC levels were predictive for the development of NP, ARDS, sepsis and lethal outcome (AUCTREC in the range 0.71–0.82, AUCKREC in the range 0.67–0.74). TREC/KREC analysis can be considered as a potential prognostic test in patients with pneumonia.

AB - Pneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbidities as well as to assess the host immune response measured by TREC/KREC levels in patients with pneumonia. The theoretical study was carried out using the Columbia Open Health Data (COHD) resource, which provides access to clinical concept prevalence and co-occurrence from electronic health records. The experimental study included TREC/KREC assays in young adults (18–40 years) with community-acquired (CAP) (n = 164) or nosocomial (NP) (n = 99) pneumonia and healthy controls (n = 170). Co-occurring rates between pneumonia, sepsis, acute respiratory distress syndrome (ARDS) and some other related conditions common in intensive care units were the top among 4170, 3382 and 963 comorbidities in pneumonia, sepsis and ARDS, respectively. CAP patients had higher TREC levels, while NP patients had lower TREC/KREC levels compared to controls. Low TREC and KREC levels were predictive for the development of NP, ARDS, sepsis and lethal outcome (AUCTREC in the range 0.71–0.82, AUCKREC in the range 0.67–0.74). TREC/KREC analysis can be considered as a potential prognostic test in patients with pneumonia.

KW - acute respiratory distress syndrome (ARDS)

KW - Columbia Open Health Data (COHD)

KW - comorbidities

KW - pneumonia

KW - sepsis

KW - TREC/KREC

KW - Intensive Care Units

KW - Sepsis/complications

KW - Humans

KW - Respiratory Distress Syndrome/epidemiology

KW - Critical Illness

KW - Young Adult

KW - Pneumonia/epidemiology

UR - http://www.scopus.com/inward/record.url?scp=85137587112&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/bb8cd9be-b16f-34d8-936f-77902698d3f8/

U2 - 10.3390/ijms23179896

DO - 10.3390/ijms23179896

M3 - Article

C2 - 36077293

AN - SCOPUS:85137587112

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 17

M1 - 9896

ER -