Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

Выдержка

4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.

Язык оригиналаанглийский
Страницы (с-по)668-672
Число страниц5
ЖурналRussian Journal of General Chemistry
Том89
Номер выпуска4
DOI
СостояниеОпубликовано - 1 апр 2019

Отпечаток

Quinazolines
Oximes
Ethers
Argon
Palladium
Amides
Amines
Derivatives
1,4-dioxane
benzamide
4-aminoquinazoline
xantphos

Предметные области Scopus

  • Химия (все)

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title = "Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile",
abstract = "4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol {\%} of [Pd2(dba)3], 0.2 mol {\%} of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.",
keywords = "4-aminoquinazolines, cross-coupling reactions, metal complex catalysis, oximes, palladium",
author = "Demakova, {M. Ya} and Islamova, {R. M.} and Suslonov, {V. V.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1134/S1070363219040054",
language = "English",
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journal = "Russian Journal of General Chemistry",
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Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile. / Demakova, M. Ya; Islamova, R. M.; Suslonov, V. V.

В: Russian Journal of General Chemistry, Том 89, № 4, 01.04.2019, стр. 668-672.

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

TY - JOUR

T1 - Palladium-Catalyzed Synthesis of 4-Aminoquinazolines from Amide Oxime Ethers and 2-Iodobenzonitrile

AU - Demakova, M. Ya

AU - Islamova, R. M.

AU - Suslonov, V. V.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - 4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.

AB - 4-Substituted O-benzyl benzamide oximes reacted with 2-iodobenzonitrile in the presence of 0.1 mol % of [Pd2(dba)3], 0.2 mol % of XantPhos, and 1.5 equiv of Cs2CO3 in dioxane under argon to give 2-arylquinazolin-4-amines. The described reaction is a new type of cascade processes, which affords 4-amino-quinazoline derivatives without using highly reactive chlorinating agents.

KW - 4-aminoquinazolines

KW - cross-coupling reactions

KW - metal complex catalysis

KW - oximes

KW - palladium

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U2 - 10.1134/S1070363219040054

DO - 10.1134/S1070363219040054

M3 - Article

VL - 89

SP - 668

EP - 672

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

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ER -