Novel brominated metabolites from Bryozoa: a functional analysis

Arina L. Maltseva, Olga N. Kotenko, Vladimir A. Kutyumov, Darya A. Matvienko, Alexey L. Shavarda, Michael K. Winson, Andrew N. Ostrovsky

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

4 Цитирования (Scopus)

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Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou
Язык оригиналаанглийский
Страницы (с-по)1840-1848
ЖурналNatural Product Research
Том31
Номер выпуска16
DOI
СостояниеОпубликовано - 2017

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    Maltseva, Arina L. ; Kotenko, Olga N. ; Kutyumov, Vladimir A. ; Matvienko, Darya A. ; Shavarda, Alexey L. ; Winson, Michael K. ; Ostrovsky, Andrew N. / Novel brominated metabolites from Bryozoa: a functional analysis. В: Natural Product Research. 2017 ; Том 31, № 16. стр. 1840-1848.
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    title = "Novel brominated metabolites from Bryozoa: a functional analysis",
    abstract = "Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou",
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    author = "Maltseva, {Arina L.} and Kotenko, {Olga N.} and Kutyumov, {Vladimir A.} and Matvienko, {Darya A.} and Shavarda, {Alexey L.} and Winson, {Michael K.} and Ostrovsky, {Andrew N.}",
    year = "2017",
    doi = "10.1080/14786419.2016.1261344",
    language = "English",
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    journal = "Natural Product Research",
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    Novel brominated metabolites from Bryozoa: a functional analysis. / Maltseva, Arina L.; Kotenko, Olga N.; Kutyumov, Vladimir A.; Matvienko, Darya A.; Shavarda, Alexey L.; Winson, Michael K.; Ostrovsky, Andrew N.

    В: Natural Product Research, Том 31, № 16, 2017, стр. 1840-1848.

    Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

    TY - JOUR

    T1 - Novel brominated metabolites from Bryozoa: a functional analysis

    AU - Maltseva, Arina L.

    AU - Kotenko, Olga N.

    AU - Kutyumov, Vladimir A.

    AU - Matvienko, Darya A.

    AU - Shavarda, Alexey L.

    AU - Winson, Michael K.

    AU - Ostrovsky, Andrew N.

    PY - 2017

    Y1 - 2017

    N2 - Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou

    AB - Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou

    KW - alkaloid

    KW - natural products

    KW - metabolites

    KW - fungicidal activity

    KW - antitumor activity

    KW - terminoflustrindole

    U2 - 10.1080/14786419.2016.1261344

    DO - 10.1080/14786419.2016.1261344

    M3 - Article

    VL - 31

    SP - 1840

    EP - 1848

    JO - Natural Product Research

    JF - Natural Product Research

    SN - 1478-6419

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    ER -