Novel brominated metabolites from Bryozoa: a functional analysis

Arina L. Maltseva, Olga N. Kotenko, Vladimir A. Kutyumov, Darya A. Matvienko, Alexey L. Shavarda, Michael K. Winson, Andrew N. Ostrovsky

Результат исследований: Научные публикации в периодических изданияхстатья

6 Цитирования (Scopus)

Выдержка

Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou
Язык оригиналаанглийский
Страницы (с-по)1840-1848
ЖурналNatural Product Research
Том31
Номер выпуска16
DOI
СостояниеОпубликовано - 2017

Отпечаток

Bryozoa
bromine
Bromine
Functional analysis
Invertebrates
Metabolites
Bioactivity
Biological Products
bioactive properties
Assays
invertebrates
Cells
cell lines
metabolites
Cell Line
assays

Цитировать

Maltseva, Arina L. ; Kotenko, Olga N. ; Kutyumov, Vladimir A. ; Matvienko, Darya A. ; Shavarda, Alexey L. ; Winson, Michael K. ; Ostrovsky, Andrew N. / Novel brominated metabolites from Bryozoa: a functional analysis. В: Natural Product Research. 2017 ; Том 31, № 16. стр. 1840-1848.
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abstract = "Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou",
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Novel brominated metabolites from Bryozoa: a functional analysis. / Maltseva, Arina L.; Kotenko, Olga N.; Kutyumov, Vladimir A.; Matvienko, Darya A.; Shavarda, Alexey L.; Winson, Michael K.; Ostrovsky, Andrew N.

В: Natural Product Research, Том 31, № 16, 2017, стр. 1840-1848.

Результат исследований: Научные публикации в периодических изданияхстатья

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T1 - Novel brominated metabolites from Bryozoa: a functional analysis

AU - Maltseva, Arina L.

AU - Kotenko, Olga N.

AU - Kutyumov, Vladimir A.

AU - Matvienko, Darya A.

AU - Shavarda, Alexey L.

AU - Winson, Michael K.

AU - Ostrovsky, Andrew N.

PY - 2017

Y1 - 2017

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AB - Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential have been discovered in recent years. Here we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumor cell lines. The gradient distribution of this compou

KW - alkaloid

KW - natural products

KW - metabolites

KW - fungicidal activity

KW - antitumor activity

KW - terminoflustrindole

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EP - 1848

JO - Natural Product Research

JF - Natural Product Research

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