Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models

Murilo S de Abreu, Ana C V V Giacomini, Rafael Genario, Nathália Rech, Júlia Carboni, Anton M Lakstygal, Tamara G Amstislavskaya, Konstantin A Demin, Brian E Leonard, Marli Vlok, Brian H Harvey, Angelo Piato, Leonardo J G Barcellos, Allan V Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

3 Цитирования (Scopus)

Аннотация

Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacotherapy and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.

Язык оригиналаанглийский
Страницы (с-по)172928
ЖурналPharmacology, Biochemistry and Behavior
DOI
СостояниеЭлектронная публикация перед печатью - 2020

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