Mucosal vaccine based on attenuated influenza virus and the group B Streptococcus recombinant peptides protected mice from influenza and S. pneumoniae infections

Yulia Desheva, Galina Leontieva, Tatiana Kramskaya, Kornelia B Grabovskaya, Vadim Karev, Andery Mamontov, Petr Nazarov, Alexander Suvorov

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

Although many influenza-related deaths are attributable to secondary bacterial infection with S. pneumoniae, vaccines that simultaneously protect against influenza and pneumococcal infection are currently not developed. The aim of our study was to evaluate the possibility to prevent post-influenza pneumococcal infection using an associated vaccine based on live influenza vaccine (LAIV) combined with recombinant polypeptides derived from superficial factors of Group B streptococcus (GBS) determining pathogenicity. We demonstrated in a model of post-influenza pneumococcal pneumonia that intranasal pneumococcal super-infection seriously complicated the course of A/Shanghai/2/2013(H7N9) CDC-RG virus infection in mice. Associated immunization using LAIV and GBS vaccine (GBSV) prevented post-influenza pneumococcal pneumonia better than mono-LAIV or GBSV immunization. At the same time, parenteral pneumococcal post-influenza infection of immune mice was more severe in the groups immunized using recombinant GBS peptides which can be explained by antibody-dependent enhancement of infection. In this case, the introduction of blockers of histamine receptors type 1 and 2 reduced the burden of secondary pneumococcal infection.

Язык оригиналаАнглийский
Номер статьиe0218544
Страницы (с-по)e0218544
Число страниц14
ЖурналPLoS ONE
Том14
Номер выпуска6
DOI
СостояниеОпубликовано - 25 июн 2019

Предметные области Scopus

  • Земледелие и биологические науки (все)
  • Общие
  • Биохимия, генетика и молекулярная биология (все)

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    Desheva, Y., Leontieva, G., Kramskaya, T., Grabovskaya, K. B., Karev, V., Mamontov, A., Nazarov, P., & Suvorov, A. (2019). Mucosal vaccine based on attenuated influenza virus and the group B Streptococcus recombinant peptides protected mice from influenza and S. pneumoniae infections. PLoS ONE, 14(6), e0218544. [e0218544]. https://doi.org/10.1371/journal.pone.0218544