MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities

Liu Cao, Alexey Gurevich, Kelsey L. Alexander, C. Benjamin Naman, Tiago Leão, Evgenia Glukhov, Tal Luzzatto-Knaan, Fernando Vargas, Robby Quinn, Amina Bouslimani, Louis Felix Nothias, Nitin K. Singh, Jon G. Sanders, Rodolfo A.S. Benitez, Luke R. Thompson, Md Nafiz Hamid, James T. Morton, Alla Mikheenko, Alexander Shlemov, Anton KorobeynikovIddo Friedberg, Rob Knight, Kasthuri Venkateswaran, William H. Gerwick, Lena Gerwick, Pieter C. Dorrestein, Pavel A. Pevzner, Hosein Mohimani

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

We have developed an efficient method for discovering ribosomally synthesized and post-translationally modified peptides with unknown post-translational modifications from microbial communities through the database search of mass spectra against peptides predicted by genome or metagenome mining. Searching eight datasets collected from various environments—including human microbiome, marine cyanobacteria, and International Space Station—resulted in the discovery of seven unknown RiPPs.

Язык оригиналаанглийский
Страницы (с-по)600-608.e4
Число страниц13
ЖурналCell Systems
Том9
Номер выпуска6
Ранняя дата в режиме онлайн16 окт 2019
DOI
СостояниеОпубликовано - 18 дек 2019

Предметные области Scopus

  • Патология и судебная медицина
  • Гистология
  • Клеточная биология

Цитировать

Cao, L., Gurevich, A., Alexander, K. L., Naman, C. B., Leão, T., Glukhov, E., Luzzatto-Knaan, T., Vargas, F., Quinn, R., Bouslimani, A., Nothias, L. F., Singh, N. K., Sanders, J. G., Benitez, R. A. S., Thompson, L. R., Hamid, M. N., Morton, J. T., Mikheenko, A., Shlemov, A., ... Mohimani, H. (2019). MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities. Cell Systems, 9(6), 600-608.e4. https://doi.org/10.1016/j.cels.2019.09.004, https://doi.org/10.1016/j.cels.2019.09.004