Mast cells in photolesion of the skin and basal cell cancer associated with it

I. O. Smirnova, I. M. Kvetnoy, N. M. Anichkov, O. N. Smirnova, I. V. Antonova

Результат исследований: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Morphofunctional features of skin mast cells located in the areas subjected to chronic UV-radiation and in the associated basal cell carcinoma with photoinjure have been studied. Various immunohistochemical methods (chromogranin A, CD1a, HLA-DR, CD35, Ki67, P53, Bcl-2, Mcl-1, involucrine) were used. It is found that chronic UV-damage leads to mast cell hyperplasia as well as activation of their synthetic, absorption and secretory functions. It is suggested that mast cell hyperplasia and increase of mast cells neuroendocrine activity provide a risk of basal cell carcinoma development.

Язык оригиналаанглийский
Страницы (с-по)26-29
Число страниц4
ЖурналArkhiv Patologii
Том67
Номер выпуска5
СостояниеОпубликовано - 6 дек 2005

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Предметные области Scopus

  • Патология и судебная медицина

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