Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites.

Денис Борисович Тихонов, Лев Гиршевич Магазаник, E.I. Nagaeva

Результат исследований: Научные публикации в периодических изданияхстатья

9 Цитирования (Scopus)

Аннотация

The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role in several physiological and pathological processes. ASIC1a are most sensitive to acidification of the external medium, which is the reason for the current interest in their function and pharmacology. Recently, the list of ASIC1a ligands has been rapidly expanding. It includes inorganic cations, a large number of synthetic and endogenous small molecules, and peptide toxins. The information on the mechanisms of action and the binding sites of the ligands comes from electrophysiological, mutational and structural studies. In the present review, we attempt to present a systematic view of the complex pattern of interactions between ligands and ASIC1a.
Язык оригиналаанглийский
Страницы (с-по)4-13
ЖурналActa Naturae (англоязычная версия)
Том11
Номер выпуска1 (40)
СостояниеОпубликовано - 2019
Опубликовано для внешнего пользованияДа

Ключевые слова

  • ASIC
  • binding sites
  • cns
  • inhibition
  • mechanisms of ligand-receptor interactions
  • potentiation

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