Involvement of the Arp2/3 complex and WASP proteins in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages

Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, S.N. Butov, V.G. Antonov, A.D. Nozdrachev

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

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Аннотация

© 2015, Pleiades Publishing, Ltd.The Fura-2AM fluorescent Ca2+ probe was used to study the possibility that the Arp2/3 complex and WASP proteins are involved in the effects of glutoxim and molixan on the intracellular Ca2+ concentration in macrophages. It has been demonstrated that preincubation of macrophages with inhibitors of the Arp2/3 complex or WASP proteins (CK-0944666 or wiskostatin, respectively) results in a significant suppression of Ca2+-responses induced by glutoxim or molixan. This suggests that polymerization of actin filaments is a process involved in the effect of glutoxim or molixan on intracellular Ca2+ concentration in macrophages.
Язык оригиналаанглийский
Страницы (с-по)279 - 282
Число страниц4
ЖурналDoklady Biochemistry and Biophysics
Том464
Номер выпуска1
DOI
СостояниеОпубликовано - 2015

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