In Vivo Production of RNA Aptamers and Nanoparticles: Problems and Prospects

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

1 Цитирования (Scopus)

Аннотация

RNA aptamers are becoming increasingly attractive due to their superior properties. This review discusses the early stages of aptamer research, the main developments in this area, and the latest technologies being developed. The review also highlights the advantages of RNA aptamers in comparison to antibodies, considering the great potential of RNA aptamers and their applications in the near future. In addition, it is shown how RNA aptamers can form endless 3-D structures, giving rise to various structural and functional possibilities. Special attention is paid to the Mango, Spinach and Broccoli fluorescent RNA aptamers, and the advantages of split RNA aptamers are discussed. The review focuses on the importance of creating a platform for the synthesis of RNA nanoparticles in vivo and examines yeast, namely Saccharomyces cerevisiae, as a potential model organism for the production of RNA nanoparticles on a large scale.

Язык оригиналаанглийский
Страницы (с-по)1422-1440
Число страниц19
ЖурналMolecules
Том26
Номер выпуска5
DOI
СостояниеОпубликовано - 6 мар 2021

Предметные области Scopus

  • Аналитическая химия
  • Химия (разное)
  • Молекулярная медицина
  • Фармация
  • Поиск новых лекарств
  • Физическая и теоретическая химия
  • Органическая химия

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