TY - JOUR

T1 - Improvement of Microvascular Function in Patients with Morbid Obesity After Bariatric Surgery Revealed by Imaging Photoplethysmography

AU - Vasilieva, ME

AU - Kashchenko, VA

AU - Shmidt, EV

AU - Mizeva, IA

AU - Dolotovskaya, PM

AU - Zaytsev, VV

AU - Margaryants, NB

AU - Kamshilin, AA

N1 - Times Cited in Web of Science Core Collection: 0 Total Times Cited: 0 Cited Reference Count: 47

PY - 2025

Y1 - 2025

N2 - Background Morbid obesity leads to serious complications such as diabetes mellitus, arterial hypertension, and atherosclerosis. Bariatric surgery aims to reduce body weight and correct metabolic disorders and associated macro- and microvascular dysfunction. Metabolic disturbances can be assessed by biochemical markers, whereas microvascular function can be assessed by the response to provocative stimuli. The aim of this work is to quantitatively assess the cutaneous microcirculatory change caused by bariatric surgery using imaging photoplethysmography. Methods The study included 20 patients with obesity whose body mass index (BMI) was greater than 40 kg/m(2) who underwent bariatric surgery and 20 control subjects. Microvascular function was assessed twice, before and 6 months after surgery, by measuring the perfusion response to local forearm heating up to 40 degrees C using imaging photoplethysmography. Results The perfusion response to local heating was found to be significantly lower in patients with obesity before surgery compared to the control group, but 6 months after surgery, it approaches indicators of the control group, along with a decrease in BMI from 48 +/- 5 to 36 +/- 5 kg/m(2), P < 0.001. Besides, bariatric surgery improves biochemical markers of metabolic syndrome (glycated hemoglobin decreases from 6.3 +/- 1.0 to 5.2 +/- 0.4% and cholesterol from 5.2 +/- 1.4 to 4.2 +/- 0.8 mmol/l). Conclusion Based on these results, we conclude that microvascular abnormalities caused by obesity could be repaired after bariatric surgery and subsequent conservative treatment.

AB - Background Morbid obesity leads to serious complications such as diabetes mellitus, arterial hypertension, and atherosclerosis. Bariatric surgery aims to reduce body weight and correct metabolic disorders and associated macro- and microvascular dysfunction. Metabolic disturbances can be assessed by biochemical markers, whereas microvascular function can be assessed by the response to provocative stimuli. The aim of this work is to quantitatively assess the cutaneous microcirculatory change caused by bariatric surgery using imaging photoplethysmography. Methods The study included 20 patients with obesity whose body mass index (BMI) was greater than 40 kg/m(2) who underwent bariatric surgery and 20 control subjects. Microvascular function was assessed twice, before and 6 months after surgery, by measuring the perfusion response to local forearm heating up to 40 degrees C using imaging photoplethysmography. Results The perfusion response to local heating was found to be significantly lower in patients with obesity before surgery compared to the control group, but 6 months after surgery, it approaches indicators of the control group, along with a decrease in BMI from 48 +/- 5 to 36 +/- 5 kg/m(2), P < 0.001. Besides, bariatric surgery improves biochemical markers of metabolic syndrome (glycated hemoglobin decreases from 6.3 +/- 1.0 to 5.2 +/- 0.4% and cholesterol from 5.2 +/- 1.4 to 4.2 +/- 0.8 mmol/l). Conclusion Based on these results, we conclude that microvascular abnormalities caused by obesity could be repaired after bariatric surgery and subsequent conservative treatment.

KW - Bariatric surgery

KW - Microcirculation

KW - Imaging photoplethysmography

KW - Microvascular function

KW - Morbid obesity

KW - ENDOTHELIAL FUNCTION

KW - GASTRIC BYPASS

KW - CARDIOVASCULAR RISK

KW - MECHANISMS

KW - OUTCOMES

KW - ATHEROSCLEROSIS

KW - VASODILATOR

KW - DYSFUNCTION

KW - MARKERS

KW - DISEASE

U2 - 10.1007/s11695-025-07741-8

DO - 10.1007/s11695-025-07741-8

M3 - статья

VL - 35

SP - 1001

EP - 1008

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

IS - 3

ER -