Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae

Yu V. Andreychuk, A. A. Shiryaeva, A. S. Zhuk, E. I. Stepchenkova, S. G. Inge-Vechtomov

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

Выдержка

Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.

Язык оригиналаанглийский
Страницы (с-по)172-174
Число страниц3
ЖурналRussian Journal of Genetics: Applied Research
Том7
Номер выпуска2
DOI
СостояниеОпубликовано - 1 мар 2017

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    Предметные области Scopus

    • Зоология и животноводство
    • Генетика
    • Агрономия и растениеводство

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    title = "Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae",
    abstract = "Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.",
    keywords = "genome stability, mutagenesis, mutational test systems, prion",
    author = "Andreychuk, {Yu V.} and Shiryaeva, {A. A.} and Zhuk, {A. S.} and Stepchenkova, {E. I.} and Inge-Vechtomov, {S. G.}",
    year = "2017",
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    Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae. / Andreychuk, Yu V.; Shiryaeva, A. A.; Zhuk, A. S.; Stepchenkova, E. I.; Inge-Vechtomov, S. G.

    В: Russian Journal of Genetics: Applied Research, Том 7, № 2, 01.03.2017, стр. 172-174.

    Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

    TY - JOUR

    T1 - Impact of prionization of the Sup35 protein [PSI+] on the frequency of genetic changes, accounted in the alpha-test in yeast Saccharomyces cerevisiae

    AU - Andreychuk, Yu V.

    AU - Shiryaeva, A. A.

    AU - Zhuk, A. S.

    AU - Stepchenkova, E. I.

    AU - Inge-Vechtomov, S. G.

    PY - 2017/3/1

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    N2 - Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.

    AB - Amyloidogenesis in nerve tissues cause human diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, and the illness of Louis Gehrig, characterized by specific neurodegenerative symptoms. The frequency of nerve cells with an abnormal number of chromosomes is increased in patients with Alzheimer’s disease. However, the direct impact of prions on the genome stability has not been sufficiently investigated. In our work, we studied the impact of the [PSI+] prions on the stability of the S. cerevisiae genome using the alpha-test system.

    KW - genome stability

    KW - mutagenesis

    KW - mutational test systems

    KW - prion

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    U2 - 10.1134/S2079059717020022

    DO - 10.1134/S2079059717020022

    M3 - Article

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    EP - 174

    JO - Russian Journal of Genetics: Applied Research

    JF - Russian Journal of Genetics: Applied Research

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