The large knee joint defects (LKJD) are one of the indications to amputation and
prosthesis. Alternative to it is reconstructive surgery based on Ilizarov method. We
present the case of a female patient with LKJD 16cm and shortening of the right
lower extremity 12cm, hypertrophic distraction regenerate of the right lower limb 6cm
and chronic osteomyelitis of the right femur. The whole period of treatment was 67
months (5.5 years). Period of osteosynthesis (period of distraction and fixation) was
43 months (3.5 years). The complications that we faced during the treatment had no
influence on good final anatomical and functional results.