Host-dependent serum specificity to the V3 domain of HIV-1

A. A. Nabatov, A. E. Masharsky, S. V. Verevochkin, A. V. Emelyanov, A. P. Kozlov

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Выдержка

The previous studies of anti-HIV-1 humoral immune response have found the stable individual structural bias in the antibody production that reflects the changes in the immune functional network caused by HIV-1. The correlation between antigen structure, in particular the V3 domain of HIV-1, and the serum specificity to the structure remains unclear. To clarify the role of host individual factors in the serum specificity, we used the slightly modified HIV-1 serotyping methodological approach for the sera of the patients infected with HIV-1 with a different level of genetic similarity. Substantial discrepancy between serum specificities and antigen structure was found. Patients infected with HIV-1 carrying similar and identical V3 sequences had significantly different serum specificities. The opposite situation was often observed as well. The results of the study suggest that the influence of the V3 loop structure in the development of humoral immune response to the V3 loop is substantially modified in a patient-specific manner.

Язык оригиналаанглийский
Страницы (с-по)471-476
Число страниц6
ЖурналScandinavian Journal of Immunology
Том60
Номер выпуска5
DOI
СостояниеОпубликовано - 1 ноя 2004

Отпечаток

HIV-1
Serum
Humoral Immunity
Antigens
Serotyping
Antibody Formation

Предметные области Scopus

  • Иммунология

Цитировать

Nabatov, A. A. ; Masharsky, A. E. ; Verevochkin, S. V. ; Emelyanov, A. V. ; Kozlov, A. P. / Host-dependent serum specificity to the V3 domain of HIV-1. В: Scandinavian Journal of Immunology. 2004 ; Том 60, № 5. стр. 471-476.
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Host-dependent serum specificity to the V3 domain of HIV-1. / Nabatov, A. A.; Masharsky, A. E.; Verevochkin, S. V.; Emelyanov, A. V.; Kozlov, A. P.

В: Scandinavian Journal of Immunology, Том 60, № 5, 01.11.2004, стр. 471-476.

Результат исследований: Научные публикации в периодических изданияхстатья

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AU - Verevochkin, S. V.

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AU - Kozlov, A. P.

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