Growth hormone treatment strategies in assisted reproduction for the poor responder patients

K. V. Ob’edkova, A. M. Gzgzyan, D. A. Niauri, L. Kh. Dzhemlikhanova, I. Yu. Kogan, I. O. Krikheli, I. D. Mekina, E. A. Lesik, E.M. Komarova, M. A. Mazilina

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

The goal of the study was to estimate the efficacy of growth hormone (GH) co-treatment to the antagonist protocol in IVF/ ICSI cycles in poor responders. A prospective observational study involved 75 patients. All patients underwent standard antagonist protocol with or without GH co-treatment. GH additional was given a daily subcutaneous injection of 1.33 mg (equivalent to 4 IU) of GH from day 1 of ovarian stimulation until the day of human chorionic gonadotropin (hCG). Concentrations of GH, insulin-like growth factor I (IGF-I) and IGF binding protein-3 (IGFBP-3) in serum and follicular fluid were analyzed. The GH co-treatment significantly lowered effective dose of gonadotropins, duration of stimulation, IGFBP-3 level in serum and follicular fluid day of oocytes retrieval. The number of oocytes recovered, metaphase II stage (MII) oocytes, 2 pronucleus (2 pn) zygote, good-quality transferred embryos were significantly higher in the GH+ group. Only patients GH+ group became pregnant. Positive correlation was found between IGF-I level in follicular fluid, dynamics of IGFBP-3 level changes during stimulation protocol and number of good-quality transferred embryos in the GH+ group. GH administration in IVF/ICSI cycles for poor responders raises ovarian sensitivity to the gonadotropin exogenous influence, this way, increasing number of high-quality embryos and the probability of pregnancy.
Язык оригиналаанглийский
Страницы (с-по)132-139
Число страниц8
Журнал ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА
Том14
Номер выпуска2
DOI
СостояниеОпубликовано - 2019

Предметные области Scopus

  • Медицина (все)

Ключевые слова

  • GROWTH HORMONE, POOR OVARIAN RESPONSE, IN VITRO FERTILIZATION (IVF), ASSISTED REPRODUCTIVE TECHNOLOGIES (ART)

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