Genetic analysis of pleiotropic effects of pho85 mutations in yeast Saccharomyces cerevisiae

E. V. Sambuk, Yu G. Popova, A. Yu Fizikova, M. V. Padkina

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Выдержка

The cyclin-dependent phosphoprotein kinase Pho85p is involved in the regulation of metabolism and cell cycle in the yeast Saccharomyces cerevisiae. It is known that mutations in the PHO85 gene lead to constitutive synthesis of Pho5p acidic phosphatase, a delay in cell growth on media containing nonfermentable carbon sources, sensitivity to high temperature, and other phenotypic effects. A lack of growth at 37°C and on a medium with alcohol as the carbon source was shown to be associated with the rapid accumulation of nuclear ts and mitochondrial [rho-] mutations occurring in the background of gene PHO85 inactivation. Thus, Pho85p seems to play an important role in the maintenance of yeast genome stability.

Язык оригиналаанглийский
Страницы (с-по)1039-1045
Число страниц7
ЖурналGenetika
Том39
Номер выпуска8
СостояниеОпубликовано - 1 дек 2003

Отпечаток

Saccharomyces cerevisiae
Carbon
Yeasts
Mutation
Cyclin-Dependent Kinases
Genomic Instability
Phosphoproteins
Gene Silencing
Growth
Phosphoric Monoester Hydrolases
Cell Cycle
Maintenance
Alcohols
Temperature
Genes

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Sambuk, E. V. ; Popova, Yu G. ; Fizikova, A. Yu ; Padkina, M. V. / Genetic analysis of pleiotropic effects of pho85 mutations in yeast Saccharomyces cerevisiae. В: Genetika. 2003 ; Том 39, № 8. стр. 1039-1045.
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abstract = "The cyclin-dependent phosphoprotein kinase Pho85p is involved in the regulation of metabolism and cell cycle in the yeast Saccharomyces cerevisiae. It is known that mutations in the PHO85 gene lead to constitutive synthesis of Pho5p acidic phosphatase, a delay in cell growth on media containing nonfermentable carbon sources, sensitivity to high temperature, and other phenotypic effects. A lack of growth at 37°C and on a medium with alcohol as the carbon source was shown to be associated with the rapid accumulation of nuclear ts and mitochondrial [rho-] mutations occurring in the background of gene PHO85 inactivation. Thus, Pho85p seems to play an important role in the maintenance of yeast genome stability.",
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Genetic analysis of pleiotropic effects of pho85 mutations in yeast Saccharomyces cerevisiae. / Sambuk, E. V.; Popova, Yu G.; Fizikova, A. Yu; Padkina, M. V.

В: Genetika, Том 39, № 8, 01.12.2003, стр. 1039-1045.

Результат исследований: Научные публикации в периодических изданияхстатья

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