Generation of two iPSC lines (FAMRCi004-A and FAMRCi004-B) from patient with familial progressive cardiac conduction disorder carrying genetic variant DSP p.His1684Arg.

Aleksandr Khudiakov, Kseniya Perepelina, Polina Klauzen, Anna Zlotina, Konstantin Gusev, Elena Kaznacheyeva, Anna Malashicheva, Anna Kostareva

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

Human iPSC cell lines (FAMRCi004-A and FAMRCi004-B) were generated from patient with progressive cardiac conduction disease and sick sinus syndrome carrying DSP p.His1684Arg genetic variant. Patient-specific adipose tissue-derived mesenchymal multipotent stromal cells were reprogrammed using non-integrative Sendai viruses. Established iPSC lines showed normal karyotype, expressed pluripotent markers and were able to differentiate toward three germ layers in vitro. The reported iPSC lines could be useful tool for in vitro modeling of progressive cardiac conduction disease associated with mutations in desmosomal genes.

Язык оригиналаанглийский
Номер статьи101720
ЖурналStem Cell Research
Том43
DOI
СостояниеОпубликовано - мар 2020

Предметные области Scopus

  • Биология развития
  • Клеточная биология

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