Functional properties of smooth muscle cells in ascending aortic aneurysm

D.A. Kostina, I.V. Voronkina, L.V. Smagina, N.D. Gavriliuk, O.M. Moiseeva, O.B. Irtiuga, V.E. Uspensky, A.A. Kostareva, A.B. Malashicheva

Результат исследований: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Thoracic aortic aneurysm (TAA) develops as a result of complex sequential events that dynamically alter the structure and composition of the aortic vascular extracellular matrix (ECM). The main cellular elements that alter the composition of aortic wall are smooth muscle cells (SMCs). The purpose of the present work was to study alterations of smooth muscle cell functions derived from the patients with TAA and from healthy donors. Since it is believed that TAA associates with bicuspid aortic valve (BAV) and with tricuspid aortic valve (TAV) differed in their pathogenesis, we have compared SMCs and tissue samples from BAV and TAV patients and healthy donors. The comparison was done by several parameters: SMC growth, migration and apoptotic dynamics, metalloproteinase MMP2 and MMP9 activity (zymography), and elastin, collagen, and fibrillin content (Western blot) in both tissue samples and cultured SMCs. Proliferation of BAV and TAV SMCs was decreased and migration ability in scratch tests was increased in TAV-
Язык оригиналаанглийский
Страницы (с-по)61-67
ЖурналCell and Tissue Biology
Номер выпуска1
DOI
СостояниеОпубликовано - 2014
Опубликовано для внешнего пользованияДа

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