From past to future: suppressor mutations in yeast genes, coding translation termination factors

Результат исследований: Научные публикации в периодических изданияхстатья

Выдержка

The study of the SUP45 and SUP35 genes of yeast Saccharomyces cerevisiae in the laboratory of Physiological Genetics of St. Petersburg State University began in 1964 when the first omnipotent nonsense suppressor mutations were obtained. During the following 55 years, a lot of information about these genes has been gained through the research efforts of various laboratories. Now we know that SUP45 and SUP35 encode translation termination factors eRF1 and eRF3, respectively. Both genes are essential, and sup45 and sup35 mutations lead not only to impaired translation but also to multiple pleiotropic effects. The aim of this review is to summarize known data about suppressor mutations in SUP45 or SUP35 genes.
Язык оригиналаанглийский
Номер статьи21
Страницы (с-по)89
Число страниц109
ЖурналBiological Communications
Том64
Номер выпуска2
DOI
СостояниеОпубликовано - 2019

Отпечаток

Genetic Suppression
Yeasts
Genes
Nonsense Codon
Essential Genes
Saccharomyces cerevisiae
Mutation
Research

Цитировать

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abstract = "The study of the SUP45 and SUP35 genes of yeast Saccharomyces cerevisiae in the laboratory of Physiological Genetics of St. Petersburg State University began in 1964 when the first omnipotent nonsense suppressor mutations were obtained. During the following 55 years, a lot of information about these genes has been gained through the research efforts of various laboratories. Now we know that SUP45 and SUP35 encode translation termination factors eRF1 and eRF3, respectively. Both genes are essential, and sup45 and sup35 mutations lead not only to impaired translation but also to multiple pleiotropic effects. The aim of this review is to summarize known data about suppressor mutations in SUP45 or SUP35 genes.",
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author = "Трубицина, {Нина Павловна} and Землянко, {Ольга Михайловна} and Москаленко, {Светлана Евгеньевна} and Журавлева, {Галина Анатольевна}",
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From past to future: suppressor mutations in yeast genes, coding translation termination factors. / Трубицина, Нина Павловна; Землянко, Ольга Михайловна; Москаленко, Светлана Евгеньевна; Журавлева, Галина Анатольевна.

В: Biological Communications, Том 64, № 2, 21, 2019, стр. 89.

Результат исследований: Научные публикации в периодических изданияхстатья

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AU - Трубицина, Нина Павловна

AU - Землянко, Ольга Михайловна

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AU - Журавлева, Галина Анатольевна

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AB - The study of the SUP45 and SUP35 genes of yeast Saccharomyces cerevisiae in the laboratory of Physiological Genetics of St. Petersburg State University began in 1964 when the first omnipotent nonsense suppressor mutations were obtained. During the following 55 years, a lot of information about these genes has been gained through the research efforts of various laboratories. Now we know that SUP45 and SUP35 encode translation termination factors eRF1 and eRF3, respectively. Both genes are essential, and sup45 and sup35 mutations lead not only to impaired translation but also to multiple pleiotropic effects. The aim of this review is to summarize known data about suppressor mutations in SUP45 or SUP35 genes.

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