FoxA expression pattern in two polychaete species, Alitta virens and Platynereis dumerilii: Examination of the conserved key regulator of the gut development from cleavage through larval life, postlarval growth, and regeneration

Roman P. Kostyuchenko, Vitaly V. Kozin, Nadezhda A. Filippova, Ekaterina V. Sorokina

Результат исследований: Научные публикации в периодических изданияхстатья

3 Цитирования (Scopus)

Выдержка

Background: foxA orthologs are involved in various processes from embryo patterning to regulation of metabolism. Since foxA conserved role in the development of the gut of errant annelids has never been thoroughly studied, we used a candidate gene approach to unravel the molecular profile of the alimentary canal in two closely related nereid worms with a trochophore-type lecithotrophic larva. Results: The character of foxA expression in the two polychaetes was similar but not identical. The genes were successively activated first in blastoporal cells, then in the stomodeum, the midgut, and hindgut primordia, and in the cells of central and peripheral nervous system. Before the start of active feeding of nectochaetes, we observed a short phase of foxA expression in the entire digestive tract. After amputation of posterior segments, foxA expression was established de novo in the new terminal part of the intestine, and then in the developing hindgut and the anus. Conclusions: We discovered an early marker of endoderm formation previously unknown in errant annelids. Its expression dynamics provided valuable insights into the gut development. Comparative analysis of foxA activity suggests its primary role in gastrulation morphogenesis independently of its type and in midgut and foregut specification.

Язык оригиналаанглийский
Страницы (с-по)728-743
Число страниц16
ЖурналDevelopmental Dynamics
Том248
Ранняя дата в режиме онлайн2018
DOI
СостояниеОпубликовано - 2019

Отпечаток

Regeneration
Gastrulation
Endoderm
Peripheral Nervous System
Anal Canal
Growth
Morphogenesis
Amputation
Genes
Intestines
Larva
Gastrointestinal Tract
Embryonic Structures
Central Nervous System

Предметные области Scopus

  • Биология развития

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title = "FoxA expression pattern in two polychaete species, Alitta virens and Platynereis dumerilii: Examination of the conserved key regulator of the gut development from cleavage through larval life, postlarval growth, and regeneration",
abstract = "Background: foxA orthologs are involved in various processes from embryo patterning to regulation of metabolism. Since foxA conserved role in the development of the gut of errant annelids has never been thoroughly studied, we used a candidate gene approach to unravel the molecular profile of the alimentary canal in two closely related nereid worms with a trochophore-type lecithotrophic larva. Results: The character of foxA expression in the two polychaetes was similar but not identical. The genes were successively activated first in blastoporal cells, then in the stomodeum, the midgut, and hindgut primordia, and in the cells of central and peripheral nervous system. Before the start of active feeding of nectochaetes, we observed a short phase of foxA expression in the entire digestive tract. After amputation of posterior segments, foxA expression was established de novo in the new terminal part of the intestine, and then in the developing hindgut and the anus. Conclusions: We discovered an early marker of endoderm formation previously unknown in errant annelids. Its expression dynamics provided valuable insights into the gut development. Comparative analysis of foxA activity suggests its primary role in gastrulation morphogenesis independently of its type and in midgut and foregut specification.",
keywords = "Digestive system, forkhead, Gradual metamorphosis, Gut morphogenesis, Lophotrochozoa, Morphallaxis, Nereididae, Nereis, Polychaeta, Reparative regeneration, Spiralia",
author = "Kostyuchenko, {Roman P.} and Kozin, {Vitaly V.} and Filippova, {Nadezhda A.} and Sorokina, {Ekaterina V.}",
year = "2019",
doi = "10.1002/dvdy.7",
language = "English",
volume = "248",
pages = "728--743",
journal = "Developmental Dynamics",
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FoxA expression pattern in two polychaete species, Alitta virens and Platynereis dumerilii : Examination of the conserved key regulator of the gut development from cleavage through larval life, postlarval growth, and regeneration. / Kostyuchenko, Roman P.; Kozin, Vitaly V.; Filippova, Nadezhda A.; Sorokina, Ekaterina V.

В: Developmental Dynamics, Том 248, 2019, стр. 728-743.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - FoxA expression pattern in two polychaete species, Alitta virens and Platynereis dumerilii

T2 - Examination of the conserved key regulator of the gut development from cleavage through larval life, postlarval growth, and regeneration

AU - Kostyuchenko, Roman P.

AU - Kozin, Vitaly V.

AU - Filippova, Nadezhda A.

AU - Sorokina, Ekaterina V.

PY - 2019

Y1 - 2019

N2 - Background: foxA orthologs are involved in various processes from embryo patterning to regulation of metabolism. Since foxA conserved role in the development of the gut of errant annelids has never been thoroughly studied, we used a candidate gene approach to unravel the molecular profile of the alimentary canal in two closely related nereid worms with a trochophore-type lecithotrophic larva. Results: The character of foxA expression in the two polychaetes was similar but not identical. The genes were successively activated first in blastoporal cells, then in the stomodeum, the midgut, and hindgut primordia, and in the cells of central and peripheral nervous system. Before the start of active feeding of nectochaetes, we observed a short phase of foxA expression in the entire digestive tract. After amputation of posterior segments, foxA expression was established de novo in the new terminal part of the intestine, and then in the developing hindgut and the anus. Conclusions: We discovered an early marker of endoderm formation previously unknown in errant annelids. Its expression dynamics provided valuable insights into the gut development. Comparative analysis of foxA activity suggests its primary role in gastrulation morphogenesis independently of its type and in midgut and foregut specification.

AB - Background: foxA orthologs are involved in various processes from embryo patterning to regulation of metabolism. Since foxA conserved role in the development of the gut of errant annelids has never been thoroughly studied, we used a candidate gene approach to unravel the molecular profile of the alimentary canal in two closely related nereid worms with a trochophore-type lecithotrophic larva. Results: The character of foxA expression in the two polychaetes was similar but not identical. The genes were successively activated first in blastoporal cells, then in the stomodeum, the midgut, and hindgut primordia, and in the cells of central and peripheral nervous system. Before the start of active feeding of nectochaetes, we observed a short phase of foxA expression in the entire digestive tract. After amputation of posterior segments, foxA expression was established de novo in the new terminal part of the intestine, and then in the developing hindgut and the anus. Conclusions: We discovered an early marker of endoderm formation previously unknown in errant annelids. Its expression dynamics provided valuable insights into the gut development. Comparative analysis of foxA activity suggests its primary role in gastrulation morphogenesis independently of its type and in midgut and foregut specification.

KW - Digestive system

KW - forkhead

KW - Gradual metamorphosis

KW - Gut morphogenesis

KW - Lophotrochozoa

KW - Morphallaxis

KW - Nereididae

KW - Nereis

KW - Polychaeta

KW - Reparative regeneration

KW - Spiralia

UR - http://www.scopus.com/inward/record.url?scp=85059568742&partnerID=8YFLogxK

U2 - 10.1002/dvdy.7

DO - 10.1002/dvdy.7

M3 - Article

AN - SCOPUS:85059568742

VL - 248

SP - 728

EP - 743

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

ER -