Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy

A. A. Khudiakov, N. A. Smolina, K. I. Perepelina, A. B. Malashicheva, A. A. Kostareva

Результат исследований: Научные публикации в периодических изданияхстатья

Выдержка

Differential diagnosis of arrhythmogenic cardiomyopathy (ACM) during the disease latent phase is a challenging clinical problem that requires identification of early ACM biomarkers. Because extracellular nucleic acids are stable, specific, and can be easily detected, they can be used as reliable biomarkers of various diseases. In this study, we analyzed the levels of extracellular microRNAs and mitochondrial DNA in the conditioned medium collected from cardiomyocytes differentiated from induced pluripotent stem cells of ACM patients and healthy donor. Several microRNAs were expressed differently by the affected and healthy cardiomyocytes; therefore, they could be considered as potential ACM biomarkers.

Язык оригиналаанглийский
Страницы (с-по)272-282
Число страниц11
ЖурналBiochemistry (Moscow)
Том84
Номер выпуска3
DOI
СостояниеОпубликовано - 1 мар 2019

Отпечаток

Biomarkers
MicroRNAs
Cardiomyopathies
Mitochondrial DNA
Cardiac Myocytes
Conditioned Culture Medium
Stem cells
Induced Pluripotent Stem Cells
Nucleic Acids
Differential Diagnosis
Tissue Donors

Предметные области Scopus

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Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy. / Khudiakov, A. A.; Smolina, N. A.; Perepelina, K. I.; Malashicheva, A. B.; Kostareva, A. A.

В: Biochemistry (Moscow), Том 84, № 3, 01.03.2019, стр. 272-282.

Результат исследований: Научные публикации в периодических изданияхстатья

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T1 - Extracellular MicroRNAs and Mitochondrial DNA as Potential Biomarkers of Arrhythmogenic Cardiomyopathy

AU - Khudiakov, A. A.

AU - Smolina, N. A.

AU - Perepelina, K. I.

AU - Malashicheva, A. B.

AU - Kostareva, A. A.

PY - 2019/3/1

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AB - Differential diagnosis of arrhythmogenic cardiomyopathy (ACM) during the disease latent phase is a challenging clinical problem that requires identification of early ACM biomarkers. Because extracellular nucleic acids are stable, specific, and can be easily detected, they can be used as reliable biomarkers of various diseases. In this study, we analyzed the levels of extracellular microRNAs and mitochondrial DNA in the conditioned medium collected from cardiomyocytes differentiated from induced pluripotent stem cells of ACM patients and healthy donor. Several microRNAs were expressed differently by the affected and healthy cardiomyocytes; therefore, they could be considered as potential ACM biomarkers.

KW - arrhythmogenic cardiomyopathy

KW - cardiomyocytes

KW - induced pluripotent stem cells

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KW - mitochondrial DNA

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