Ellipsoid Body and Medulla Defects and Locomotion Disturbances in sbr (small bristles) Mutants of Drosophila melanogaster

A. O. Yakimova, E. V. Golubkova, S. V. Sarantseva, L. A. Mamon

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

Выдержка

The sbr gene is an ortholog of evolutionarily conservative nxf1 (nuclear export factor) genes that control nuclear-cytoplasmic transport of mRNA in various eukaryotic organisms. Mutations of sbr exhibit a broad range of pleiotropic effects, which are characteristic of “housekeeping” genes. Certain allele-specific manifestations of the sbr gene in neurogenesis and behavior facilitate a deeper understanding of not only universal but also highly specialized functions of this gene. Among such characteristic features of adult males with an sbr12 mutation are reduced locomotor activity as revealed in the negative geotaxis test and significant morphological disruptions of the ellipsoid body and the medulla, both of which are important for locomotion. The character of defects in the ellipsoid body and the medulla suggests that the SBR protein is essential for the normal formation and functioning of these nerve centers, and that the protein carries not only universal but also specialized functions.

Язык оригиналаанглийский
Страницы (с-по)609-617
Число страниц9
ЖурналRussian Journal of Genetics
Том54
Номер выпуска6
DOI
СостояниеОпубликовано - 1 июн 2018

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    Предметные области Scopus

    • Генетика

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    title = "Ellipsoid Body and Medulla Defects and Locomotion Disturbances in sbr (small bristles) Mutants of Drosophila melanogaster",
    abstract = "The sbr gene is an ortholog of evolutionarily conservative nxf1 (nuclear export factor) genes that control nuclear-cytoplasmic transport of mRNA in various eukaryotic organisms. Mutations of sbr exhibit a broad range of pleiotropic effects, which are characteristic of “housekeeping” genes. Certain allele-specific manifestations of the sbr gene in neurogenesis and behavior facilitate a deeper understanding of not only universal but also highly specialized functions of this gene. Among such characteristic features of adult males with an sbr12 mutation are reduced locomotor activity as revealed in the negative geotaxis test and significant morphological disruptions of the ellipsoid body and the medulla, both of which are important for locomotion. The character of defects in the ellipsoid body and the medulla suggests that the SBR protein is essential for the normal formation and functioning of these nerve centers, and that the protein carries not only universal but also specialized functions.",
    keywords = "ellipsoid body, locomotor behavior, neurogenesis, nxf1 (nuclear export factor), optic lobe, sbr (small bristles)",
    author = "Yakimova, {A. O.} and Golubkova, {E. V.} and Sarantseva, {S. V.} and Mamon, {L. A.}",
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    Ellipsoid Body and Medulla Defects and Locomotion Disturbances in sbr (small bristles) Mutants of Drosophila melanogaster. / Yakimova, A. O.; Golubkova, E. V.; Sarantseva, S. V.; Mamon, L. A.

    В: Russian Journal of Genetics, Том 54, № 6, 01.06.2018, стр. 609-617.

    Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

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    AU - Yakimova, A. O.

    AU - Golubkova, E. V.

    AU - Sarantseva, S. V.

    AU - Mamon, L. A.

    PY - 2018/6/1

    Y1 - 2018/6/1

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