Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells

D. I. Sokolov, T. Yu. Lvova, L. S. Okorokova, Ksenia Lvovna Belyakova, A. R. Sheveleva, O. I. Stepanova, V. A. Mikhailova, S. A. Sel'kov

    Результат исследований: Научные публикации в периодических изданияхстатья

    3 Цитирования (Scopus)

    Аннотация

    Despite ample data on cytokine secretion in the uteroplacental interface, the influence of microenvironment cells, in particular, trophoblast cells on angiogenesis and the role of cytokines in this process remain poorly studied. We studied the influence of cytokines on the formation of tube-like structures by endothelial cells in the presence of trophoblast cells and showed that trophoblast cells suppressed the angiogenic potential of endothelial cells. Antiangiogenic cytokines IFN-gamma, IL-10, TNF-alpha, and TGF beta via modulation of trophoblast cells stimulated the formation of tube-like structures by endothelial cells. In the co-culture of endothelial and trophoblast cells, the effects of cytokines changed and they gained additional regulatory functions.

    Язык оригиналаАнглийский
    Страницы (с-по)148-158
    Число страниц11
    ЖурналBulletin of Experimental Biology and Medicine
    Том163
    Номер выпуска1
    DOI
    СостояниеОпубликовано - мая 2017

    Предметные области Scopus

    • Биохимия, генетика и молекулярная биология (все)

    Fingerprint Подробные сведения о темах исследования «Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Sokolov, D. I., Lvova, T. Y., Okorokova, L. S., Belyakova, K. L., Sheveleva, A. R., Stepanova, O. I., Mikhailova, V. A., & Sel'kov, S. A. (2017). Effect of Cytokines on the Formation Tube-Like Structures by Endothelial Cells in the Presence of Trophoblast Cells. Bulletin of Experimental Biology and Medicine, 163(1), 148-158. https://doi.org/10.1007/s10517-017-3756-4