E-cadherin as a novel surface marker of spermatogonial stem cells

E. N. Tolkunova, A. B. Malashicheva, E. V. Chikhirzhina, E. I. Kostyleva, W. Zeng, J. Luo, I. Dobrinski, A. Hierholzer, R. Kemler, A. N. Tomilin

Результат исследований: Научные публикации в периодических изданияхстатья

9 Цитирования (Scopus)

Аннотация

Spermatogenesis is a fundamental biological process that ensures the transition of a gene from one ganeration to another via male gametes. This process relies on a rare population of testicular cells called spermatogonial stem cells (SSCs), which self-renew throughout adult male life and differentiate into mature gametes. Despite the longstanding study of SSCs, their biological properties remain largely unknown, which is partly due to the very limited availability of these cells. Here, we show that cell adhesion protein E-cadherin is a highly specific surface marker of mouse SSCs that can be successfully used to enrich them.

Язык оригиналаанглийский
Страницы (с-по)103-109
Число страниц7
ЖурналCell and Tissue Biology
Том3
Номер выпуска2
DOI
СостояниеОпубликовано - 22 мая 2009

Предметные области Scopus

  • Клеточная биология

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