E-cadherin as a novel sere ace marker of spermatogonial stem cells

E. N. Tolkunova, A. B. Malashicheva, E. V. Chikhirjina, E. I. Kostyleva, W. Zeng, J. Luo, I. Dobrinski, A. Hierholzer, R. Kemler, A. N. Tomilin

Результат исследований: Научные публикации в периодических изданияхстатья

5 Цитирования (Scopus)

Аннотация

Spermatogenesis is a fundamental biological process that ensures gee transmission from one generation to another trough gametes. This process relies on a rare population of testicular cells, called spermatogonial stem cells (SSCs), that self-renew throughout adult male life and differentiate into mature gametes. Despite the longstanding research of SSCs, their biological properties remain largely unknown which is partly due to very limited availability of these cells. Here we show that cell adhesion protein E-cadherin is a highly specific surface marker of mouse SSCs, which can be successfully used for their enrichment.

Язык оригиналаанглийский
Страницы (с-по)212-218
Число страниц7
ЖурналЦитология
Том51
Номер выпуска3
СостояниеОпубликовано - 1 дек 2009

Предметные области Scopus

  • Патология и судебная медицина
  • Гистология

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