Dimensions of GSK3 Monoamine-Related Intracellular Signaling in Schizophrenia

Gohar Fakhfouri, Jivan Khlghatyan, Ilya Sukhanov, Raul R. Gainetdinov, Jean Martin Beaulieu

Результат исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийглава/разделнаучнаярецензирование


Since the discovery of the mechanism of action of typical antipsychotics in 1975, the dopamine theory of schizophrenia remains one of the principal doctrines to explain the pathogenesis of schizophrenia. According to this theory, increased dopaminergic neurotransmission involving D2 receptors results in dysregulation of intracellular signaling mechanisms, leading to manifestations of schizophrenia. D2 receptors signal through G protein-dependent and G protein-independent pathways, the latter involving Akt/GSK3 has proved to play a major role to the schizopheric phenotypes. GSK3 is known to play central roles in the regulation of metabolism, synaptic plasticity, and neurodevelopment. Moreover, several prominent risk factors and contributors of the disease converge on these downstream effectors of D2 receptor signaling. Finally, the medications used clinically for the management of schizophrenia affect this signaling pathway. Here, we review the signaling systems altered in schizophrenia with a focus on GSK3 networks and discuss their involvement in the pathophysiology of the disease as well as their potential for the development of diagnostic and therapeutic tools.

Язык оригиналаанглийский
Название основной публикацииHandbook of Behavioral Neuroscience
Число страниц16
СостояниеОпубликовано - 1 янв 2016

Серия публикаций

НазваниеHandbook of Behavioral Neuroscience
ISSN (печатное издание)1569-7339


Предметные области Scopus

  • Когнитивная нейробиология
  • Певеденческая неврология


Fakhfouri, G., Khlghatyan, J., Sukhanov, I., Gainetdinov, R. R., & Beaulieu, J. M. (2016). Dimensions of GSK3 Monoamine-Related Intracellular Signaling in Schizophrenia. В Handbook of Behavioral Neuroscience (стр. 447-462). (Handbook of Behavioral Neuroscience; Том 23). Elsevier. https://doi.org/10.1016/B978-0-12-800981-9.00026-2