Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties

Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ruponen, Arto Urtti

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

4 Цитирования (Scopus)

Выдержка

Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.

Язык оригиналаанглийский
Страницы (с-по)1446-1457
ЖурналDrug Discovery Today
Том24
Номер выпуска8
Ранняя дата в режиме онлайн1 янв 2019
DOI
СостояниеОпубликовано - 2019

Отпечаток

Drug Delivery Systems
Pharmaceutical Preparations
Biological Availability
Drug Liberation
Drug Compounding
Pharmacokinetics
Research Personnel

Предметные области Scopus

  • Фармакология
  • Поиск новых лекарств

Ключевые слова

  • интраокулярная доставка лекарств

Цитировать

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Design principles of ocular drug delivery systems : importance of drug payload, release rate, and material properties. / Subrizi, Astrid; del Amo, Eva M.; Korzhikov-Vlakh, Viktor; Tennikova, Tatiana; Ruponen, Marika; Urtti, Arto.

В: Drug Discovery Today, Том 24, № 8, 2019, стр. 1446-1457.

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

TY - JOUR

T1 - Design principles of ocular drug delivery systems

T2 - importance of drug payload, release rate, and material properties

AU - Subrizi, Astrid

AU - del Amo, Eva M.

AU - Korzhikov-Vlakh, Viktor

AU - Tennikova, Tatiana

AU - Ruponen, Marika

AU - Urtti, Arto

PY - 2019

Y1 - 2019

N2 - Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.

AB - Ocular drugs are usually delivered locally to the eye. Required drug loading, release rate, and ocular retention time of drug delivery systems depend on the potency, bioavailability, and clearance of the drug at the target site. Drug-loading capacity of the formulation is limited by the material properties and size constraints of the eye. The design aid described herein for ocular drug delivery systems guides the calculation of steady-state drug concentrations in the ocular compartments, taking into account drug dose, bioavailability, and clearance. The dosing rate can be adjusted to reach the target drug concentrations, thereby guiding the design of drug delivery systems for topical, intravitreal, and subconjunctival administration. The simple design aid can be used at early stages of drug development by investigators without expertise in pharmacokinetic and pharmacodynamic modeling. Successful drug delivery to ocular targets depends on ocular biology, drug properties, and formulation characteristics. A multifactorial design aid for ocular drug delivery is presented.

KW - интраокулярная доставка лекарств

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