In this study, the possibility of U-Th-He dating of pyrite is explained and then substantiated by isotope geochemistry. The first U-Th-He age obtained for 9 pyrite samples from the VMS type Uzelga deposit, Urals (377±8 Ma; MSWD 1.2) is in good agreement with independent biostratigraphic age estimations (380-390 Ma). This leads to the conclusion that pyrite can be used as a U-Th-He mineral geochronometer. Based on the results of step-heating experiments and U-Th-He age estimations it is shown that chalcopyrite, bornite and pyrrhotite are unlikely to be used in geochronology. The relative ease of U-Th-He dating in comparison with other geochronological methods makes this approach interesting for further application.