DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Anton M. Lakstygal, Tatiana O. Kolesnikova, Sergey L. Khatsko, Konstantin N. Zabegalov, Andrey D. Volgin, Konstantin A. Demin, Vadim A. Shevyrin, Edina A. Wappler-Guzzetta, Allan V. Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

16 Цитирования (Scopus)

Аннотация

Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.

Язык оригиналаанглийский
Страницы (с-по)2144-2159
Число страниц16
ЖурналACS Chemical Neuroscience
Том10
Номер выпуска5
DOI
СостояниеОпубликовано - 15 мая 2019

Предметные области Scopus

  • Биохимия
  • Физиология
  • Когнитивная нейробиология
  • Клеточная биология

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