DARK Classics in Chemical Neuroscience: Arecoline

Andrey D. Volgin, Alim Bashirzade, Tamara G. Amstislavskaya, Oleg A. Yakovlev, Konstantin A. Demin, Ying Jui Ho, Dongmei Wang, Vadim A. Shevyrin, Dongni Yan, Zhichong Tang, Jingtao Wang, Mengyao Wang, Erik T. Alpyshov, Nazar Serikuly, Edina A. Wappler-Guzzetta, Anton M. Lakstygal, Allan V. Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

Выдержка

Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

Язык оригиналаанглийский
Страницы (с-по)2176-2185
Число страниц10
ЖурналACS Chemical Neuroscience
Том10
Номер выпуска5
DOI
СостояниеОпубликовано - 15 мая 2019

Отпечаток

Arecoline
Areca
Neurosciences
Neurology
Nicotine
Central Nervous System
Neuropharmacology
Southeastern Asia
Substance Withdrawal Syndrome
Nuts
Pharmacokinetics
Nicotinic Receptors
Muscarinic Receptors
Caffeine
Alkaloids
Metabolism
Animals
Animal Models
History
Alcohols

Предметные области Scopus

  • Биохимия
  • Физиология
  • Когнитивная нейробиология
  • Клеточная биология

Цитировать

Volgin, A. D., Bashirzade, A., Amstislavskaya, T. G., Yakovlev, O. A., Demin, K. A., Ho, Y. J., ... Kalueff, A. V. (2019). DARK Classics in Chemical Neuroscience: Arecoline. ACS Chemical Neuroscience, 10(5), 2176-2185. https://doi.org/10.1021/acschemneuro.8b00711
Volgin, Andrey D. ; Bashirzade, Alim ; Amstislavskaya, Tamara G. ; Yakovlev, Oleg A. ; Demin, Konstantin A. ; Ho, Ying Jui ; Wang, Dongmei ; Shevyrin, Vadim A. ; Yan, Dongni ; Tang, Zhichong ; Wang, Jingtao ; Wang, Mengyao ; Alpyshov, Erik T. ; Serikuly, Nazar ; Wappler-Guzzetta, Edina A. ; Lakstygal, Anton M. ; Kalueff, Allan V. / DARK Classics in Chemical Neuroscience : Arecoline. В: ACS Chemical Neuroscience. 2019 ; Том 10, № 5. стр. 2176-2185.
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abstract = "Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.",
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Volgin, AD, Bashirzade, A, Amstislavskaya, TG, Yakovlev, OA, Demin, KA, Ho, YJ, Wang, D, Shevyrin, VA, Yan, D, Tang, Z, Wang, J, Wang, M, Alpyshov, ET, Serikuly, N, Wappler-Guzzetta, EA, Lakstygal, AM & Kalueff, AV 2019, 'DARK Classics in Chemical Neuroscience: Arecoline', ACS Chemical Neuroscience, том. 10, № 5, стр. 2176-2185. https://doi.org/10.1021/acschemneuro.8b00711

DARK Classics in Chemical Neuroscience : Arecoline. / Volgin, Andrey D.; Bashirzade, Alim; Amstislavskaya, Tamara G.; Yakovlev, Oleg A.; Demin, Konstantin A.; Ho, Ying Jui; Wang, Dongmei; Shevyrin, Vadim A.; Yan, Dongni; Tang, Zhichong; Wang, Jingtao; Wang, Mengyao; Alpyshov, Erik T.; Serikuly, Nazar; Wappler-Guzzetta, Edina A.; Lakstygal, Anton M.; Kalueff, Allan V.

В: ACS Chemical Neuroscience, Том 10, № 5, 15.05.2019, стр. 2176-2185.

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

TY - JOUR

T1 - DARK Classics in Chemical Neuroscience

T2 - Arecoline

AU - Volgin, Andrey D.

AU - Bashirzade, Alim

AU - Amstislavskaya, Tamara G.

AU - Yakovlev, Oleg A.

AU - Demin, Konstantin A.

AU - Ho, Ying Jui

AU - Wang, Dongmei

AU - Shevyrin, Vadim A.

AU - Yan, Dongni

AU - Tang, Zhichong

AU - Wang, Jingtao

AU - Wang, Mengyao

AU - Alpyshov, Erik T.

AU - Serikuly, Nazar

AU - Wappler-Guzzetta, Edina A.

AU - Lakstygal, Anton M.

AU - Kalueff, Allan V.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

AB - Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

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KW - animal models

KW - Arecoline

KW - clinical effects

KW - nicotine-like action

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U2 - 10.1021/acschemneuro.8b00711

DO - 10.1021/acschemneuro.8b00711

M3 - Review article

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VL - 10

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JO - ACS Chemical Neuroscience

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Volgin AD, Bashirzade A, Amstislavskaya TG, Yakovlev OA, Demin KA, Ho YJ и соавт. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chemical Neuroscience. 2019 Май 15;10(5):2176-2185. https://doi.org/10.1021/acschemneuro.8b00711