DARK Classics in Chemical Neuroscience: Arecoline

Andrey D. Volgin, Alim Bashirzade, Tamara G. Amstislavskaya, Oleg A. Yakovlev, Konstantin A. Demin, Ying Jui Ho, Dongmei Wang, Vadim A. Shevyrin, Dongni Yan, Zhichong Tang, Jingtao Wang, Mengyao Wang, Erik T. Alpyshov, Nazar Serikuly, Edina A. Wappler-Guzzetta, Anton M. Lakstygal, Allan V. Kalueff

Результат исследований: Научные публикации в периодических изданияхОбзорная статьярецензирование

11 Цитирования (Scopus)

Аннотация

Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

Язык оригиналаанглийский
Страницы (с-по)2176-2185
Число страниц10
ЖурналACS Chemical Neuroscience
Том10
Номер выпуска5
DOI
СостояниеОпубликовано - 15 мая 2019

Предметные области Scopus

  • Биохимия
  • Физиология
  • Когнитивная нейробиология
  • Клеточная биология

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