Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy

Yehuda Shoenfeld, Varvara Rabkova, Carmen Scheibenbogen, Louise Brinth, Manuel Martinez-Lavin, Shuichi Ikeda, Harald Heidecke, Abdulla Watad, Nicola L. Bragazzi, Joab Chapman, Leonid P. Churilov, Howard Amital

Результат исследований: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and
silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the
pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence
regarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune comorbidities,
alteration in immune cell subsets, production of autoantibodies and presentation in animal models.
These syndromes could be incorporated in a new concept of autoimmune neurosensory dysautonomia with the
common denominators of autoantibodies against G-protein coupled receptors and small fiber neuropathy.
Sjogren's syndrome, which is a classical autoimmune disease, could serve as a disease model, illustrating the
concept. Development of this concept aims to identify an apparently autoimmune subgroup of the disputable
disorders, addressed in the review, which may most benefit from the immunotherapy.
Язык оригиналаанглийский
Номер статьи108384
Число страниц11
ЖурналClinical Immunology
Том214
СостояниеОпубликовано - 18 мар 2020

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Shoenfeld, Y., Rabkova, V., Scheibenbogen, C., Brinth, L., Martinez-Lavin, M., Ikeda, S., ... Amital, H. (2020). Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. Clinical Immunology, 214, [108384].