Сравнительно-геномный анализ бактерия рода Holospora, внутриядерных симбионтов парамеций

Sofya K. Garushyants, Alexandra Y. Beliavskaia, Dmitry B. Malko, Maria D. Logacheva, Maria S. Rautian, Mikhail S. Gelfand

Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

Выдержка

While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.

Переведенное названиеСравнительно-геномный анализ бактерия рода Holospora, внутриядерных симбионтов парамеций
Язык оригиналаанглийский
Номер статьи738
Страницы (с-по)738
Число страниц11
ЖурналFrontiers in Microbiology
Том9
Номер выпускаAPR
DOI
СостояниеОпубликовано - 16 апр 2018

Ключевые слова

    Предметные области Scopus

    • Микробиология (медицинская)
    • Микробиология

    Цитировать

    Garushyants, Sofya K. ; Beliavskaia, Alexandra Y. ; Malko, Dmitry B. ; Logacheva, Maria D. ; Rautian, Maria S. ; Gelfand, Mikhail S. / Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia. В: Frontiers in Microbiology. 2018 ; Том 9, № APR. стр. 738.
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    abstract = "While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.",
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    author = "Garushyants, {Sofya K.} and Beliavskaia, {Alexandra Y.} and Malko, {Dmitry B.} and Logacheva, {Maria D.} and Rautian, {Maria S.} and Gelfand, {Mikhail S.}",
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    language = "English",
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    Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia. / Garushyants, Sofya K.; Beliavskaia, Alexandra Y.; Malko, Dmitry B.; Logacheva, Maria D.; Rautian, Maria S.; Gelfand, Mikhail S.

    В: Frontiers in Microbiology, Том 9, № APR, 738, 16.04.2018, стр. 738.

    Результат исследований: Научные публикации в периодических изданияхстатьянаучнаярецензирование

    TY - JOUR

    T1 - Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia

    AU - Garushyants, Sofya K.

    AU - Beliavskaia, Alexandra Y.

    AU - Malko, Dmitry B.

    AU - Logacheva, Maria D.

    AU - Rautian, Maria S.

    AU - Gelfand, Mikhail S.

    PY - 2018/4/16

    Y1 - 2018/4/16

    N2 - While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.

    AB - While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.

    KW - Ciliates

    KW - Endosymbionts

    KW - Genome

    KW - Holospora

    KW - Nuclear symbionts

    KW - Paramecia

    KW - Rickettsiales

    KW - endosymbionts

    KW - ciliates

    KW - IDENTIFICATION

    KW - nuclear symbionts

    KW - genome

    KW - PERIPLASMIC PROTEIN

    KW - EVOLUTION

    KW - INFECTION PROCESS

    KW - CAUDATUM

    KW - DATABASE

    KW - ELEGANS

    KW - FREE-LIVING BACTERIA

    KW - INSECTS

    KW - OBTUSA

    KW - paramecia

    UR - http://www.scopus.com/inward/record.url?scp=85045765981&partnerID=8YFLogxK

    U2 - 10.3389/fmicb.2018.00738

    DO - 10.3389/fmicb.2018.00738

    M3 - Article

    VL - 9

    SP - 738

    JO - Frontiers in Microbiology

    JF - Frontiers in Microbiology

    SN - 1664-302X

    IS - APR

    M1 - 738

    ER -