Collapsed monomolecular thin films as surface nanomodification techniques for bioorganic MALDI analysis

E.S. Silyavka, A.A. Selyutin, N.G. Sukhodolov, V.V. Shilovskikh, P.A. Oleneva, A.A. Mitrofanov, O.A. Keltsieva, P.S. Dubakova, V.N. Babakov, M.L. Alexandrova, N.V. Krasnov, E.P. Podolskaya

Результат исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

A modification method of the target for Matrix Assisted Laser Desorption/Ionization (MALDI) analysis by metal-affinity sorbents was proposed. Monolayers of metal stearates obtained in the geometry of the drop perform as such sorbents. The formation of monolayers was proved by optical microscopy and the Laser Desorption/Ionization (LDI) method. The surface of the substrate after modification studied using scanning electron microscopy. Metal-affinity extraction of human serum albumin adducts with soman was carried out at the modified target surface. MALDI mass spectrometric analysis demonstrated that signals corresponding to adducts are present in mass spectra.

Язык оригиналаанглийский
Название основной публикацииInternational Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018
ИздательAmerican Institute of Physics
ISBN (печатное издание)9780735417922
DOI
СостояниеОпубликовано - 15 янв 2019
СобытиеInternational Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018 - Moscow, Российская Федерация
Продолжительность: 17 окт 201819 окт 2018

Серия публикаций

НазваниеAIP Conference Proceedings
ИздательAmerican Institute of Physics
Номер1
Том2064
ISSN (печатное издание)0094-243X

Конференция

КонференцияInternational Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018
СтранаРоссийская Федерация
ГородMoscow
Период17/10/1819/10/18

Предметные области Scopus

  • Физика и астрономия (все)

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  • Цитировать

    Silyavka, E. S., Selyutin, A. A., Sukhodolov, N. G., Shilovskikh, V. V., Oleneva, P. A., Mitrofanov, A. A., Keltsieva, O. A., Dubakova, P. S., Babakov, V. N., Alexandrova, M. L., Krasnov, N. V., & Podolskaya, E. P. (2019). Collapsed monomolecular thin films as surface nanomodification techniques for bioorganic MALDI analysis. В International Conference on State-of-the-Art Trends of Scientific Research of Artificial and Natural Nanoobjects, STRANN 2018 [030015] (AIP Conference Proceedings; Том 2064, № 1). American Institute of Physics. https://doi.org/10.1063/1.5087677