Cohesion of Cortical Language Networks During Word Processing Is Predicted by a Common Polymorphism in the SETBP1 Gene

Natalia Rakhlin, Nicole Landi, Maria Lee, James S. Magnuson, Oxana Yu Naumova, Irina V. Ovchinnikova, Elena L. Grigorenko

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The etiological mechanisms of the genetic underpinnings of developmental language disorder (DLD) are unknown, in part due to the behavioral heterogeneity of the disorder's manifestations. In this study, we explored an association between the SETBP1 gene (18q21.1), revealed in a genome-wide association study of DLD in a geographically isolated population, and brain network-based endophenotypes of functional intracortical coherence between major language-related brain areas. We analyzed electroencephalogram (EEG) data from thirty-nine children (twenty-three with, sixteen without DLD) aged 7.17–15.83 years acquired during an auditory picture–word matching paradigm. Variation at a single nucleotide polymorphism in the intronic region of the SETBP1 gene, rs8085464, explained 19% of the variance in intracortical network cohesion (p =.00478). This suggests that the development of these brain networks might be partially associated with the variation in SETBP1.

Язык оригиналаанглийский
Страницы (с-по)131-155
ЖурналNew Directions for Child and Adolescent Development
Том2020
Номер выпуска169
Ранняя дата в режиме онлайн23 апр 2020
DOI
СостояниеОпубликовано - 2020

Предметные области Scopus

  • Социопсихология
  • Психология обучения и развития

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