To compare the clinical acceptability of micronized purified flavonoid fraction (MPFF)
1000mg with MPFF 500mg tablets, administered at the same daily dose in patients suffering noncomplicated acute hemorrhoids.
Background: MPFF is an established treatment for hemorrhoidal disease.
Methods: This was a double-blind, multi-center, randomized study. Patients took either MPFF 1000mgor 500mg tablets for 7 days (daily dose; 3 g over 4 days followed by 2 g over 3 days). Adverse events were recorded in a patient diary. On day 7, anal pain and bleeding were assessed (visual analog scale [VAS] and Dimitroulopoulos scale, respectively).
Results: Patients (162) were randomized to MPFF 1000mg (79) and MPFF 500mg (83). No serious
adverse events (AEs) occurred; 10 emergent AEs were considered treatment-related (6 for MPFF
1000mg and 4 for 500 mg). Both regimens were associated with significant reduction in anal pain
(VAS); 2.37 cm MPFF 1000mg (P