Cellular transparency in vivo: the search for possible mechanisms

A. Zayas , L. Zueva, D. Rios, D. Meshalkina, V. Makarov, A. Volnova, I. Kucheryavikh, M. Inyushin

Результат исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийиная часть книжной публикации

Выдержка

Why one particular cell in vivo is transparent while another is not? Modern methods of in vivo optical imaging: in vivo optical recording of cellular activity, fluorescent probe cellular microchemistry, neuronal optostimulation, optogenetics, in vivo arteriosclerotic research: all these technologies would benefit from in vivo transparent tissue. Using optical and electron microscopy immunostaining methods we have found that αA-crystallin protein abundantly present in transparent cells of the vertebrates optical tract (crystal lens, cornea), is also present in other transparent cells from the retina (Müller cells, cones) from different vertebrate classes (birds, anurans, mammals). Abundancy of one particular substance in exclusively transparent cells in vertebrates suggest that αA-crystallins can be the cause of the cellular transparency: two possible physical mechanisms are discussed. This finding may help to develop the genetic approach to make cells transparent: the gene αA-crystallins are well known, for transgenes with αA-crystallins abundantly expressed in neurons and astrocytes may have a very transparent brain, animals with naturally transparent skin can be developed as well. Development of model animals with transparent tissue is only one of possible outcomes, this work may contribute do general knowledge on the genetics of biological transparency. This work has been supported by NIH SC2GM111149 Grant.
Язык оригиналаанглийский
Название основной публикацииАктуальные проблемы трансляционной биомедицины - 2018
Подзаголовок основной публикацииСборник тезисов
Место публикацииСПБ.
ИздательИздательство Санкт-Петербургского университета
Страницы78
СостояниеОпубликовано - 2018
Событие4-я ежегодная конференция Института Трансляционной
биомедицины СПбГУ (ИТБМ СПбГУ) «Актуальные проблемы трансляционной биомедицины - 2018»
- Санкт-Петербург, Российская Федерация
Продолжительность: 20 июл 201822 июл 2018

Конференция

Конференция4-я ежегодная конференция Института Трансляционной
биомедицины СПбГУ (ИТБМ СПбГУ) «Актуальные проблемы трансляционной биомедицины - 2018»
СтранаРоссийская Федерация
ГородСанкт-Петербург
Период20/07/1822/07/18

Отпечаток

Crystallins
Vertebrates
Microchemistry
Optogenetics
Optical Imaging
Transgenes
Fluorescent Dyes
Astrocytes
Cornea
Lenses
Birds
Retina
Mammals
Electron Microscopy
Animal Models
Technology
Neurons
Skin
Brain
Research

Предметные области Scopus

  • Нейробиология (все)

Цитировать

Zayas , A., Zueva, L., Rios, D., Meshalkina, D., Makarov, V., Volnova, A., ... Inyushin, M. (2018). Cellular transparency in vivo: the search for possible mechanisms. В Актуальные проблемы трансляционной биомедицины - 2018: Сборник тезисов (стр. 78). СПБ.: Издательство Санкт-Петербургского университета.
Zayas , A. ; Zueva, L. ; Rios, D. ; Meshalkina, D. ; Makarov, V. ; Volnova, A. ; Kucheryavikh, I. ; Inyushin, M. / Cellular transparency in vivo: the search for possible mechanisms. Актуальные проблемы трансляционной биомедицины - 2018: Сборник тезисов. СПБ. : Издательство Санкт-Петербургского университета, 2018. стр. 78
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Zayas , A, Zueva, L, Rios, D, Meshalkina, D, Makarov, V, Volnova, A, Kucheryavikh, I & Inyushin, M 2018, Cellular transparency in vivo: the search for possible mechanisms. в Актуальные проблемы трансляционной биомедицины - 2018: Сборник тезисов. Издательство Санкт-Петербургского университета, СПБ., стр. 78, Санкт-Петербург, Российская Федерация, 20/07/18.

Cellular transparency in vivo: the search for possible mechanisms. / Zayas , A.; Zueva, L.; Rios, D.; Meshalkina, D.; Makarov, V.; Volnova, A.; Kucheryavikh, I.; Inyushin, M.

Актуальные проблемы трансляционной биомедицины - 2018: Сборник тезисов. СПБ. : Издательство Санкт-Петербургского университета, 2018. стр. 78.

Результат исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийиная часть книжной публикации

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AU - Zayas , A.

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AU - Kucheryavikh, I.

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Zayas A, Zueva L, Rios D, Meshalkina D, Makarov V, Volnova A и соавт. Cellular transparency in vivo: the search for possible mechanisms. В Актуальные проблемы трансляционной биомедицины - 2018: Сборник тезисов. СПБ.: Издательство Санкт-Петербургского университета. 2018. стр. 78