Biological evaluation and molecular dynamics simulation of water-soluble fullerene derivative C60[C(COOH)2]3

Ivan N. Gaponenko, Sergei V. Ageev, Gleb O. Iurev, Olga S. Shemchuk, Anatolii A. Meshcheriakov, Andrey V. Petrov, Irina L. Solovtsova, Lubov V. Vasina, Tatiana B. Tennikova, Igor V. Murin, Konstantin N. Semenov, Vladimir V. Sharoyko

Результат исследований: Научные публикации в периодических изданияхстатьярецензирование

5 Цитирования (Scopus)


One of the most studied fullerene members, C60, has a potential of application in various fields of biomedicine including reactive oxygen species (ROS) scavenging activity, inhibiting of tumours development, inactivating of viruses and bacteria, as well as elaboration of diagnostic and targeted drug delivery tools. However, the hydrophobicity of this molecule impedes its practical use, therefore the actuality of the research devoted to functionalisation of fullerenes leading to amphiphilic derivatives remains important. In this work, the water-soluble carboxylated fullerene derivative C60[C(COOH)2]3 was studied. Extensive biomedical investigation of this compound, namely, the binding with human serum albumin (HSA), radical scavenging activity in the reaction with diphenylpicrylhydrazyl (DPPH) radical, photodynamic properties, cytotoxicity in human embryonic kidney (HEK293) cell line, erythrocytes' haemolysis, platelet aggregation, and genotoxicity in human peripheral mononuclear cells (PBMC) was conducted. Moreover, the dynamic and structural characteristics of C60[C(COOH)2]3–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution of C60[C(COOH)2]3 associates was measured.

Язык оригиналаанглийский
Номер статьи104683
ЖурналToxicology in Vitro
Ранняя дата в режиме онлайн19 окт 2019
СостояниеОпубликовано - фев 2020

Предметные области Scopus

  • Токсикология

Ключевые слова

  • carboxylated fullerene
  • cytotoxicity
  • genotoxicity
  • radical scavenging activity
  • haemolysis
  • platelet aggregation

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