Выдержка

One of the most studied fullerene members, C60, has a potential of application in various fields of biomedicine including reactive oxygen species (ROS) scavenging activity, inhibiting of tumours development, inactivating of viruses and bacteria, as well as elaboration of diagnostic and targeted drug delivery tools. However, the hydrophobicity of this molecule impedes its practical use, therefore the actuality of the research devoted to functionalisation of fullerenes leading to amphiphilic derivatives remains important. In this work, the water-soluble carboxylated fullerene derivative C60[C(COOH)2]3 was studied. Extensive biomedical investigation of this compound, namely, the binding with human serum albumin (HSA), radical scavenging activity in the reaction with diphenylpicrylhydrazyl (DPPH) radical, photodynamic properties, cytotoxicity in human embryonic kidney (HEK293) cell line, erythrocytes' haemolysis, platelet aggregation, and genotoxicity in human peripheral mononuclear cells (PBMC) was conducted. Moreover, the dynamic and structural characteristics of C60[C(COOH)2]3–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution of C60[C(COOH)2]3 associates was measured.

Язык оригиналаанглийский
Номер статьи104683
ЖурналToxicology in Vitro
Том62
Ранняя дата в режиме онлайн19 окт 2019
DOI
СостояниеОпубликовано - фев 2020

Отпечаток

Fullerenes
Molecular Dynamics Simulation
Molecular dynamics
Scavenging
Derivatives
Water
Computer simulation
HEK293 Cells
Cytotoxicity
Hydrophobicity
Platelets
Hemolysis
Hydrophobic and Hydrophilic Interactions
Platelet Aggregation
Viruses
Serum Albumin
Tumors
Reactive Oxygen Species
Bacteria
Agglomeration

Предметные области Scopus

  • Токсикология

Ключевые слова

  • carboxylated fullerene
  • cytotoxicity
  • genotoxicity
  • radical scavenging activity
  • haemolysis
  • platelet aggregation

Цитировать

@article{f1911059a757432ba7b3e87fc212c913,
title = "Biological evaluation and molecular dynamics simulation of water-soluble fullerene derivative C60[C(COOH)2]3",
abstract = "One of the most studied fullerene members, C60, has a potential of application in various fields of biomedicine including reactive oxygen species (ROS) scavenging activity, inhibiting of tumours development, inactivating of viruses and bacteria, as well as elaboration of diagnostic and targeted drug delivery tools. However, the hydrophobicity of this molecule impedes its practical use, therefore the actuality of the research devoted to functionalisation of fullerenes leading to amphiphilic derivatives remains important. In this work, the water-soluble carboxylated fullerene derivative C60[C(COOH)2]3 was studied. Extensive biomedical investigation of this compound, namely, the binding with human serum albumin (HSA), radical scavenging activity in the reaction with diphenylpicrylhydrazyl (DPPH) radical, photodynamic properties, cytotoxicity in human embryonic kidney (HEK293) cell line, erythrocytes' haemolysis, platelet aggregation, and genotoxicity in human peripheral mononuclear cells (PBMC) was conducted. Moreover, the dynamic and structural characteristics of C60[C(COOH)2]3–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution of C60[C(COOH)2]3 associates was measured.",
keywords = "Carboxylated fullerene, Cytotoxicity, Genotoxicity, Haemolysis, Platelet aggregation, Radical scavenging activity, carboxylated fullerene, cytotoxicity, genotoxicity, radical scavenging activity, haemolysis, platelet aggregation",
author = "Gaponenko, {Ivan N.} and Ageev, {Sergei V.} and Iurev, {Gleb O.} and Shemchuk, {Olga S.} and Meshcheriakov, {Anatolii A.} and Petrov, {Andrey V.} and Solovtsova, {Irina L.} and Vasina, {Lubov V.} and Tennikova, {Tatiana B.} and Murin, {Igor V.} and Semenov, {Konstantin N.} and Sharoyko, {Vladimir V.}",
year = "2020",
month = "2",
doi = "10.1016/j.tiv.2019.104683",
language = "English",
volume = "62",
journal = "Toxicology in Vitro",
issn = "0887-2333",
publisher = "Elsevier",

}

Biological evaluation and molecular dynamics simulation of water-soluble fullerene derivative C60[C(COOH)2]3. / Gaponenko, Ivan N.; Ageev, Sergei V.; Iurev, Gleb O.; Shemchuk, Olga S.; Meshcheriakov, Anatolii A.; Petrov, Andrey V.; Solovtsova, Irina L.; Vasina, Lubov V.; Tennikova, Tatiana B.; Murin, Igor V.; Semenov, Konstantin N.; Sharoyko, Vladimir V.

В: Toxicology in Vitro, Том 62, 104683, 02.2020.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Biological evaluation and molecular dynamics simulation of water-soluble fullerene derivative C60[C(COOH)2]3

AU - Gaponenko, Ivan N.

AU - Ageev, Sergei V.

AU - Iurev, Gleb O.

AU - Shemchuk, Olga S.

AU - Meshcheriakov, Anatolii A.

AU - Petrov, Andrey V.

AU - Solovtsova, Irina L.

AU - Vasina, Lubov V.

AU - Tennikova, Tatiana B.

AU - Murin, Igor V.

AU - Semenov, Konstantin N.

AU - Sharoyko, Vladimir V.

PY - 2020/2

Y1 - 2020/2

N2 - One of the most studied fullerene members, C60, has a potential of application in various fields of biomedicine including reactive oxygen species (ROS) scavenging activity, inhibiting of tumours development, inactivating of viruses and bacteria, as well as elaboration of diagnostic and targeted drug delivery tools. However, the hydrophobicity of this molecule impedes its practical use, therefore the actuality of the research devoted to functionalisation of fullerenes leading to amphiphilic derivatives remains important. In this work, the water-soluble carboxylated fullerene derivative C60[C(COOH)2]3 was studied. Extensive biomedical investigation of this compound, namely, the binding with human serum albumin (HSA), radical scavenging activity in the reaction with diphenylpicrylhydrazyl (DPPH) radical, photodynamic properties, cytotoxicity in human embryonic kidney (HEK293) cell line, erythrocytes' haemolysis, platelet aggregation, and genotoxicity in human peripheral mononuclear cells (PBMC) was conducted. Moreover, the dynamic and structural characteristics of C60[C(COOH)2]3–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution of C60[C(COOH)2]3 associates was measured.

AB - One of the most studied fullerene members, C60, has a potential of application in various fields of biomedicine including reactive oxygen species (ROS) scavenging activity, inhibiting of tumours development, inactivating of viruses and bacteria, as well as elaboration of diagnostic and targeted drug delivery tools. However, the hydrophobicity of this molecule impedes its practical use, therefore the actuality of the research devoted to functionalisation of fullerenes leading to amphiphilic derivatives remains important. In this work, the water-soluble carboxylated fullerene derivative C60[C(COOH)2]3 was studied. Extensive biomedical investigation of this compound, namely, the binding with human serum albumin (HSA), radical scavenging activity in the reaction with diphenylpicrylhydrazyl (DPPH) radical, photodynamic properties, cytotoxicity in human embryonic kidney (HEK293) cell line, erythrocytes' haemolysis, platelet aggregation, and genotoxicity in human peripheral mononuclear cells (PBMC) was conducted. Moreover, the dynamic and structural characteristics of C60[C(COOH)2]3–H2O binary system were obtained using molecular dynamic (MD) method, and size distribution of C60[C(COOH)2]3 associates was measured.

KW - Carboxylated fullerene

KW - Cytotoxicity

KW - Genotoxicity

KW - Haemolysis

KW - Platelet aggregation

KW - Radical scavenging activity

KW - carboxylated fullerene

KW - cytotoxicity

KW - genotoxicity

KW - radical scavenging activity

KW - haemolysis

KW - platelet aggregation

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U2 - 10.1016/j.tiv.2019.104683

DO - 10.1016/j.tiv.2019.104683

M3 - Article

C2 - 31639450

AN - SCOPUS:85074150018

VL - 62

JO - Toxicology in Vitro

JF - Toxicology in Vitro

SN - 0887-2333

M1 - 104683

ER -