Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy: Experience from the Nordic ARVC Registry

Переведенное название: Фибрилляция предсердий как клиническая характеристика аритмогенной кардиомиопатии правого желудочка: опыт из Скандинавского регистра АКМП.

Maria A Baturova, Kristina H Haugaa, Henrik K Jensen, Anneli Svensson, Thomas Gilljam, Henning Bundgaard, Trine Madsen, Jim Hansen, Monica Chivulescu, Morten Krogh Christiansen, Jonas Carlson, Thor Edvardsen, Jesper H Svendsen, Pyotr G Platonov

    Результат исследований: Научные публикации в периодических изданияхстатья

    1 цитирование (Scopus)

    Выдержка

    BACKGROUND: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations.

    METHODS: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010.

    RESULTS: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001).

    CONCLUSION: AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.

    Язык оригиналаанглийский
    Страницы (с-по)39-43
    Число страниц5
    ЖурналInternational Journal of Cardiology
    Том298
    Ранняя дата в режиме онлайн30 июл 2019
    DOI
    СостояниеОпубликовано - 1 янв 2020

    Отпечаток

    Arrhythmogenic Right Ventricular Dysplasia
    Atrial Fibrillation
    Registries
    Disease Progression
    Genotype
    Advisory Committees
    Cardiomyopathies
    Phenotype

    Предметные области Scopus

    • Кардиология и сердечно-сосудистая медицина

    Цитировать

    Baturova, Maria A ; Haugaa, Kristina H ; Jensen, Henrik K ; Svensson, Anneli ; Gilljam, Thomas ; Bundgaard, Henning ; Madsen, Trine ; Hansen, Jim ; Chivulescu, Monica ; Christiansen, Morten Krogh ; Carlson, Jonas ; Edvardsen, Thor ; Svendsen, Jesper H ; Platonov, Pyotr G. / Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy : Experience from the Nordic ARVC Registry. В: International Journal of Cardiology. 2020 ; Том 298. стр. 39-43.
    @article{3010f94596ef48b18fc23c27eed62acb,
    title = "Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy: Experience from the Nordic ARVC Registry",
    abstract = "BACKGROUND: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations.METHODS: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43{\%} females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010.RESULTS: AF was diagnosed in 42 patients (10{\%}): in 41 patients with definite ARVC diagnosis (14{\%}) vs in one genotype-positive family member (1{\%}), p < 0.001. The median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2{\%} in those with score 3 vs 13{\%} in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001).CONCLUSION: AF is seen in 14{\%} of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.",
    keywords = "Arrhythmogenic cardiomyopathy, Atrial fibrillation, Diagnostic score, ARRHYTHMIAS, TACHYARRHYTHMIAS, MANAGEMENT, PATHOLOGY",
    author = "Baturova, {Maria A} and Haugaa, {Kristina H} and Jensen, {Henrik K} and Anneli Svensson and Thomas Gilljam and Henning Bundgaard and Trine Madsen and Jim Hansen and Monica Chivulescu and Christiansen, {Morten Krogh} and Jonas Carlson and Thor Edvardsen and Svendsen, {Jesper H} and Platonov, {Pyotr G}",
    note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
    year = "2020",
    month = "1",
    day = "1",
    doi = "10.1016/j.ijcard.2019.07.086",
    language = "English",
    volume = "298",
    pages = "39--43",
    journal = "International Journal of Cardiology",
    issn = "0167-5273",
    publisher = "Elsevier",

    }

    Baturova, MA, Haugaa, KH, Jensen, HK, Svensson, A, Gilljam, T, Bundgaard, H, Madsen, T, Hansen, J, Chivulescu, M, Christiansen, MK, Carlson, J, Edvardsen, T, Svendsen, JH & Platonov, PG 2020, 'Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy: Experience from the Nordic ARVC Registry', International Journal of Cardiology, том. 298, стр. 39-43. https://doi.org/10.1016/j.ijcard.2019.07.086

    Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy : Experience from the Nordic ARVC Registry. / Baturova, Maria A; Haugaa, Kristina H; Jensen, Henrik K; Svensson, Anneli; Gilljam, Thomas; Bundgaard, Henning; Madsen, Trine; Hansen, Jim; Chivulescu, Monica; Christiansen, Morten Krogh; Carlson, Jonas; Edvardsen, Thor; Svendsen, Jesper H; Platonov, Pyotr G.

    В: International Journal of Cardiology, Том 298, 01.01.2020, стр. 39-43.

    Результат исследований: Научные публикации в периодических изданияхстатья

    TY - JOUR

    T1 - Atrial fibrillation as a clinical characteristic of arrhythmogenic right ventricular cardiomyopathy

    T2 - Experience from the Nordic ARVC Registry

    AU - Baturova, Maria A

    AU - Haugaa, Kristina H

    AU - Jensen, Henrik K

    AU - Svensson, Anneli

    AU - Gilljam, Thomas

    AU - Bundgaard, Henning

    AU - Madsen, Trine

    AU - Hansen, Jim

    AU - Chivulescu, Monica

    AU - Christiansen, Morten Krogh

    AU - Carlson, Jonas

    AU - Edvardsen, Thor

    AU - Svendsen, Jesper H

    AU - Platonov, Pyotr G

    N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

    PY - 2020/1/1

    Y1 - 2020/1/1

    N2 - BACKGROUND: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations.METHODS: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010.RESULTS: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001).CONCLUSION: AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.

    AB - BACKGROUND: Recent studies in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic manifestation of ARVC and as an indicator of atrial involvement in the disease progression. We aimed to assess the prevalence of AF in the Scandinavian cohort of ARVC patients and to evaluate its association with disease clinical manifestations.METHODS: Study sample comprised of 293 definite ARVC patients by 2010 Task Force criteria (TFC2010) and 141 genotype-positive family members (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of major (2 points) and minor (1 point) criteria in all categories of the TFC2010.RESULTS: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related to the ARVC diagnostic score: it significantly increased starting with the diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, p = 0.023) and increased further with increased diagnostic score (Somer's d value is 0.074, p < 0.001).CONCLUSION: AF is seen in 14% of definite ARVC patients and is related to the severity of disease phenotype thus suggesting AF being an arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial involvement in the disease progression.

    KW - Arrhythmogenic cardiomyopathy

    KW - Atrial fibrillation

    KW - Diagnostic score

    KW - ARRHYTHMIAS

    KW - TACHYARRHYTHMIAS

    KW - MANAGEMENT

    KW - PATHOLOGY

    UR - http://www.scopus.com/inward/record.url?scp=85077103190&partnerID=8YFLogxK

    UR - http://www.mendeley.com/catalogue/atrial-fibrillation-clinical-characteristic-arrhythmogenic-right-ventricular-cardiomyopathy-experien

    U2 - 10.1016/j.ijcard.2019.07.086

    DO - 10.1016/j.ijcard.2019.07.086

    M3 - Article

    C2 - 31387820

    VL - 298

    SP - 39

    EP - 43

    JO - International Journal of Cardiology

    JF - International Journal of Cardiology

    SN - 0167-5273

    ER -