Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles.

Jan Janouškovec, Gita G. Paskerova, Tatiana S. Miroliubova, Kirill V. Mikhailov, Thomas Birley, Vladimir V. Aleoshin, Timur G. Simdyanov

Результат исследований: Научные публикации в периодических изданияхстатья

Выдержка

The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.
Язык оригиналаанглийский
Номер статьи49662
Число страниц24
ЖурналeLife
Том8
Ранняя дата в режиме онлайн16 авг 2019
DOI
СостояниеОпубликовано - 16 авг 2019

Отпечаток

Chloroplast Proteins
Plastids
plastid
Pathogens
Organelles
parasite
Parasites
Genes
Innovation
Apicoplasts
Apicomplexa
Plasmodium
Eukaryota
Transcriptome
eukaryote
Genome
parasitism
innovation
genome
pathogen

Предметные области Scopus

  • Науки об окружающей среде (все)
  • Биохимия, генетика и молекулярная биология (все)

Цитировать

Janouškovec, Jan ; Paskerova, Gita G. ; Miroliubova, Tatiana S. ; Mikhailov, Kirill V. ; Birley, Thomas ; Aleoshin, Vladimir V. ; Simdyanov, Timur G. / Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles. В: eLife. 2019 ; Том 8.
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abstract = "The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.",
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Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles. / Janouškovec, Jan; Paskerova, Gita G. ; Miroliubova, Tatiana S. ; Mikhailov, Kirill V.; Birley, Thomas; Aleoshin, Vladimir V.; Simdyanov, Timur G.

В: eLife, Том 8, 49662, 16.08.2019.

Результат исследований: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles.

AU - Janouškovec, Jan

AU - Paskerova, Gita G.

AU - Miroliubova, Tatiana S.

AU - Mikhailov, Kirill V.

AU - Birley, Thomas

AU - Aleoshin, Vladimir V.

AU - Simdyanov, Timur G.

PY - 2019/8/16

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N2 - The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.

AB - The phylum Apicomplexa comprises human pathogens such as Plasmodium but are also an under-explored hotspot of evolutionary diversity central to understanding the origins of parasitism and non-photosynthetic plastids. We generated single-cell transcriptomes for all major apicomplexan groups lacking large-scale sequence data. Phylogenetic analysis reveals that apicomplexan-like parasites are polyphyletic and their similar morphologies emerged convergently at least three times. Gregarines and eugregarines are monophyletic, against most expectations, and rhytidocystids and Eleutheroschizon are sister lineages to medically important taxa. Although previously unrecognized, plastids in deep-branching apicomplexans are common, and they contain some of the most divergent and AT-rich genomes ever found. In eugregarines, however, plastids are either abnormally reduced or absent, thus increasing known plastid losses in eukaryotes from two to four. Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin.

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