Atranorin is one of the main secondary metabolites of lichens of the group of depsides, which are of considerable interest due to their biological properties. Recently, its antioxidant and antiglycating properties, which may be important in the fight against the aging process and the development of age-related diseases, such as diabetes and neurodegenerative disorders, have attracted the active attention of researchers. The antioxidant action of atranorin is due to the neutralization of free radicals, which prevents oxidative damage to cells. Atranorin also exhibits antiglycation properties suppressing protein glycation, which can reduce the risk of complications in metabolic disorders. © 2025 Elsevier B.V., All rights reserved.