An Integrated Approach for Monitoring Cell Senescence. Cell senescence. Chapter 26

Tatiana V. Pospelova, Zhanna V. Chitikova, Valery A. Pospelov

Результат исследований: Публикации в книгах, отчётах, сборниках, трудах конференцийглава/раздел

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Аннотация

Cellular senescence is considered as a crucial mechanism of tumor suppression that helps to prevent the growth of cells at risk for neoplastic transformation. In normal cells, cellular senescence induces an irreversible cell cycle arrest in response to telomere dysfunction, oncogene activation, genotoxic stress and a persistent DNA damage response (DDR). This process is accompanied by dramatic changes in cell morphology as well as in the activity of several signaling pathways. The senescent phenotype is multifaceted. In addition to an obligatory proliferation arrest, senescent cells manifest various senescence markers: mTOR-mediated hypertrophic growth (cell size increase), cell fl attening, senescence-associated β galactosidase (SA- β gal) staining, expression of negative cell cycle regulators p53, p21 Waf1 and p16 Ink4a , speci fi c chromatin reorganization including DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS), senescence- associated secretory phenotype (SASP) and other featur
Язык оригиналаанглийский
Название основной публикацииMethods in Molecular Biology. Methods and Protocols
ИздательHumana Press
Страницы538, 383-408
ISBN (печатное издание)978-1-62703-238-4
DOI
СостояниеОпубликовано - 2013
Опубликовано для внешнего пользованияДа

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