An efficient method of synthesis of isoxazolidine-fused β-lactams via base-promoted cyclization–ring opening of carbamoyl-spirocyclopropane isoxazolidines

T.Q. Tran, R.S. Savinkov, V.V. Diev, G.L. Starova, A.P. Molchanov

Результат исследований: Научные публикации в периодических изданияхстатья

13 Цитирования (Scopus)

Аннотация

1,3-Dipolar cycloadditions of dialkyl-substituted 2-benzylidenecyclopropane-1,1-dicarboxylates and a number of C-carbamoyl nitrones proceed with high efficiency and selectivity with the formation of single isomeric spiro[cyclopropane-1,4-isoxazolidine] cycloadduct. Obtained cycloadducts easily undergo cyclopropyl ring opening-cyclization to form new beta-lactams fused with isoxazolidine ring in high yields. (C) 2013 Elsevier Ltd. All rights reserved.
Язык оригиналаанглийский
Страницы (с-по)5173-5177
Число страниц5
ЖурналTetrahedron
Том69
Номер выпуска25
DOI
СостояниеОпубликовано - 2013

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