An Eco-Friendly Stereoselective Synthesis of Novel Derivatives of Indeno[1,2-b]Pyrrole and Indeno[1,2-c]Pyridazine

Vladimir L. Gein, Natalia V. Nosova, Andrei N. Yankin, Alina Y. Bazhina, Maksim V. Dmitriev

Результат исследований: Научные публикации в периодических изданияхстатья

Аннотация

A highly efficient and simple synthesis of a number of pharmaceutically interesting functionalized indenopirrole derivatives has been developed via the reaction of ninhydrin and acetoacetic acid amides in ethanol at the absence of catalyst at room temperature. In the case, then N,N-dialkylacetoacetamides were used as the methylene components, novel N,N-dialkyl-3-oxobutanamide derivatives were received. The novel indenopyridazine derivatives were first obtained via the reaction of indenopirroles with hydrazine. Environmental friendliness, mild reaction conditions, simple work-up avoiding chromatographic purification, and excellent yields are the important features of this protocol.

Язык оригиналаанглийский
ЖурналPolycyclic Aromatic Compounds
Ранняя дата в режиме онлайн17 апр 2019
DOI
СостояниеОпубликовано - 2019

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Предметные области Scopus

  • Химия материалов
  • Пластик и полимеры
  • Органическая химия

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