TY - JOUR

T1 - Amino acid-stabilized luminescent gold clusters for sensing pterin and its analogues

AU - Сыч, Томаш Сергеевич

AU - Шеховцов, Николай Викторович

AU - Буглак, Андрей Андреевич

AU - Кононов, Алексей Игоревич

PY - 2024/6/11

Y1 - 2024/6/11

N2 - Pteridines are important low molecular weight biomarkers used in diagnostics of inflammation, oxidative stress, phenylketonuria, cancer, etc. In this experimental study we present a simple and selective approach to determine...Pteridines are important low molecular weight biomarkers used in diagnostics of inflammation, oxidative stress, phenylketonuria, cancer, etc. In this experimental study we present a simple and selective approach to determine pteridines (pterin, leucopterin and folic acid) and nucleobase guanine concentration using luminescent gold clusters stabilized by aromatic amino acids. We synthesized several new gold clusters (AA-Au NCs) stabilized by various aromatic amino acids – 3,4-Dihydroxy-L-phenylalanine (DOPA), L-Tryptophan (Trp), L-Tyrosine (Tyr) and L-Phenylalanine (Phe) emitting in the violet-green spectral range. Their luminescence appeared to be sensitive to the presence of pterin, leucopterin, folic acid and guanine in dependence of the stabilizing matrix. Thus, a facile and cost-effective approach for pteridines detection is proposed. The AA-Au NC-based sensors work according to “turn-off” as well as to “turn-on” mechanisms. The possible physical origins of the luminescent quenching and enhancement are discussed.

AB - Pteridines are important low molecular weight biomarkers used in diagnostics of inflammation, oxidative stress, phenylketonuria, cancer, etc. In this experimental study we present a simple and selective approach to determine...Pteridines are important low molecular weight biomarkers used in diagnostics of inflammation, oxidative stress, phenylketonuria, cancer, etc. In this experimental study we present a simple and selective approach to determine pteridines (pterin, leucopterin and folic acid) and nucleobase guanine concentration using luminescent gold clusters stabilized by aromatic amino acids. We synthesized several new gold clusters (AA-Au NCs) stabilized by various aromatic amino acids – 3,4-Dihydroxy-L-phenylalanine (DOPA), L-Tryptophan (Trp), L-Tyrosine (Tyr) and L-Phenylalanine (Phe) emitting in the violet-green spectral range. Their luminescence appeared to be sensitive to the presence of pterin, leucopterin, folic acid and guanine in dependence of the stabilizing matrix. Thus, a facile and cost-effective approach for pteridines detection is proposed. The AA-Au NC-based sensors work according to “turn-off” as well as to “turn-on” mechanisms. The possible physical origins of the luminescent quenching and enhancement are discussed.

KW - птерины

KW - кластеры золота

KW - фолиевая кислота

KW - люминесценция

UR - https://www.mendeley.com/catalogue/2f89f5ba-2f5e-3a29-9b41-8531fa6f94c8/

U2 - 10.1039/d4ay00700j

DO - 10.1039/d4ay00700j

M3 - статья

VL - 16

SP - 4607

EP - 4618

JO - Analytical Methods

JF - Analytical Methods

SN - 1759-9660

ER -