Achievements in the synthesis of cyclooctynes for ring strain-promoted [3+2] azide-alkyne cycloaddition

Evgeny G. Chupakhin, Mikhail Yu Krasavin

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

7 Цитирования (Scopus)

Выдержка

[Figure not available: see fulltext.] The aim of this review is to present the entire range of cyclooctynes that are currently known in the literature. We provide a generalized and systematic overview of methods for their synthesis and consider the applications of cyclooctynes for the purposes of molecular biology and cellular engineering. The importance of cyclooctynes for [3+2] azide-alkyne cycloaddition is demonstrated, as the high reactivity of cyclooctynes allows to perform this reaction under mild conditions without a catalyst.

Язык оригиналаанглийский
Страницы (с-по)483-501
Число страниц19
ЖурналChemistry of Heterocyclic Compounds
Том54
Номер выпуска5
DOI
СостояниеОпубликовано - 1 мая 2018

Отпечаток

Molecular biology
Alkynes
Azides
Cycloaddition
Catalysts

Предметные области Scopus

  • Органическая химия

Цитировать

@article{24a5ad4335584318b866f839c9618c75,
title = "Achievements in the synthesis of cyclooctynes for ring strain-promoted [3+2] azide-alkyne cycloaddition",
abstract = "[Figure not available: see fulltext.] The aim of this review is to present the entire range of cyclooctynes that are currently known in the literature. We provide a generalized and systematic overview of methods for their synthesis and consider the applications of cyclooctynes for the purposes of molecular biology and cellular engineering. The importance of cyclooctynes for [3+2] azide-alkyne cycloaddition is demonstrated, as the high reactivity of cyclooctynes allows to perform this reaction under mild conditions without a catalyst.",
keywords = "cyclooctynes, fluorescence microscopy, in situ click chemistry, SPAAC reactions, visualization of living cell, [3+2] azide-alkyne cycloaddition reactions",
author = "Chupakhin, {Evgeny G.} and Krasavin, {Mikhail Yu}",
year = "2018",
month = "5",
day = "1",
doi = "10.1007/s10593-018-2295-x",
language = "English",
volume = "54",
pages = "483--501",
journal = "Chemistry of Heterocyclic Compounds",
issn = "0009-3122",
publisher = "Springer",
number = "5",

}

Achievements in the synthesis of cyclooctynes for ring strain-promoted [3+2] azide-alkyne cycloaddition. / Chupakhin, Evgeny G.; Krasavin, Mikhail Yu.

В: Chemistry of Heterocyclic Compounds, Том 54, № 5, 01.05.2018, стр. 483-501.

Результат исследований: Научные публикации в периодических изданияхОбзорная статья

TY - JOUR

T1 - Achievements in the synthesis of cyclooctynes for ring strain-promoted [3+2] azide-alkyne cycloaddition

AU - Chupakhin, Evgeny G.

AU - Krasavin, Mikhail Yu

PY - 2018/5/1

Y1 - 2018/5/1

N2 - [Figure not available: see fulltext.] The aim of this review is to present the entire range of cyclooctynes that are currently known in the literature. We provide a generalized and systematic overview of methods for their synthesis and consider the applications of cyclooctynes for the purposes of molecular biology and cellular engineering. The importance of cyclooctynes for [3+2] azide-alkyne cycloaddition is demonstrated, as the high reactivity of cyclooctynes allows to perform this reaction under mild conditions without a catalyst.

AB - [Figure not available: see fulltext.] The aim of this review is to present the entire range of cyclooctynes that are currently known in the literature. We provide a generalized and systematic overview of methods for their synthesis and consider the applications of cyclooctynes for the purposes of molecular biology and cellular engineering. The importance of cyclooctynes for [3+2] azide-alkyne cycloaddition is demonstrated, as the high reactivity of cyclooctynes allows to perform this reaction under mild conditions without a catalyst.

KW - cyclooctynes

KW - fluorescence microscopy

KW - in situ click chemistry

KW - SPAAC reactions

KW - visualization of living cell

KW - [3+2] azide-alkyne cycloaddition reactions

UR - http://www.scopus.com/inward/record.url?scp=85049588943&partnerID=8YFLogxK

U2 - 10.1007/s10593-018-2295-x

DO - 10.1007/s10593-018-2295-x

M3 - Review article

AN - SCOPUS:85049588943

VL - 54

SP - 483

EP - 501

JO - Chemistry of Heterocyclic Compounds

JF - Chemistry of Heterocyclic Compounds

SN - 0009-3122

IS - 5

ER -