Abnormal Membrane Localization of α2 Isoform of Na,K-ATPase in m. soleus of Dysferlin-Deficient Mice

V.V. Kravtsova, E.V. Bouzinova, V.V. Matchkov , N.A. Timonina, G.F. Zakyrjanova, A.L. Zefirov, I.I. Krivoi

Результат исследований: Научные публикации в периодических изданияхстатья

3 Цитирования (Scopus)

Аннотация

Dysferlin protein plays a key role in the multimolecular complex responsible for the maintenance of sarcolemma integrity and skeletal muscle cell functioning. We studied the membrane distribution of nicotinic acetylcholine receptors and α2 isoform of Na,K-ATPase in motor endplates of m. soleus in dysferlin-deficient Bla/J mice (a dysferlinopathy model). Endplates of Bla/J mice were characterized by increased area (without changes in fragmentation degree) and reduced density of the membrane distribution of nicotinic acetylcholine receptors in comparison with the corresponding parameters in control С57Bl/6 mice. The density of the membrane distribution of α2 isoform of Na,K-ATPase was also reduced, but the level of the corresponding mRNA remained unchanged. It can be hypothesized that abnormal membrane localization of α2 isoform of Na,K-ATPase results from adaptive skeletal muscle remodeling under conditions of chronic motor dysfunction.

Язык оригиналаанглийский
Страницы (с-по)593-597
ЖурналBulletin of Experimental Biology and Medicine
Том166
Номер выпуска5
Ранняя дата в режиме онлайн23 мар 2019
DOI
СостояниеОпубликовано - 2019

Предметные области Scopus

  • Биохимия, генетика и молекулярная биология (все)

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